The discovery and implementation of antibiotics in the early twentieth century transformed
human health and wellbeing. Chemical synthesis enabled the development of the first …

In studying the evolution of organic chemistry and grasping its essence, one comes quickly
to the conclusion that no other type of reaction plays as large a role in shaping this domain …

To create a drug, nature's blueprints often have to be improved through semisynthesis or
total synthesis (chemical postevolution). Selected contributions from industrial and academic …

Organomagnesium reagents occupy a central position in synthetic organic and
organometallic chemistry. Recently, the halogen–magnesium exchange has considerably …

The war against infectious bacteria is not over! Although vancomycin and glycopeptide
antibiotics have provided a strong last line of defence against many drug‐resistant bacteria …

Wenn man die Entwicklung der organischen Chemie betrachtet, kommt man schnell zu dem
Schluss, dass kein Reaktionstyp dieses Gebiet in vergleichbarer Weise geprägt hat wie die …

Antibiotics are precious resources in the fight to combat bacterial infections caused by
pathogenic organisms. Vancomycin is one of the antibiotics of last resort in the treatment of …

Abstract Triazenes (RN N NR′ R ″) are a class of compounds that hold much promise
in preparative chemistry as they are reactive groups which are both stable and adaptable to …

In the second half of the twentieth century much effort was invested in the preparation of
highly reactive polar organometallic reagents. The high reactivity of these reagents …

Ever since the world‐shaping discovery of penicillin, nature's molecular diversity has been
extensively screened for new medications and lead compounds in drug discovery. The …