Tick-borne encephalitis (TBE) is an illness caused by tick-borne encephalitis virus (TBEV)
infection which is often limited to a febrile illness, but may lead to very aggressive …

This is the second of two invited articles reviewing the development of nucleoside analogue
antiviral drugs, written for a target audience of virologists and other non-chemists, as well as …

Infections with flaviviruses, such as dengue, West Nile virus and the recently re-emerging
Zika virus, are an increasing and probably lasting global risk. This Review summarizes and …

Nucleoside analogs represent the largest class of small molecule-based antivirals, which
currently form the backbone of chemotherapy of chronic infections caused by HIV, hepatitis …

With several US Food and Drug Administration (FDA)-approved drugs and high barriers to
resistance, nucleoside and nucleotide analogs remain the cornerstone of antiviral therapies …

Deazapurine (pyrrolo [2, 3‐d] pyrimidine) nucleosides are important analogues of biogenic
purine nucleosides with diverse biological activities. Replacement of the N7 atom with a …

With Remdesivir being approved by FDA as a drug for the treatment of Corona Virus
Disease 2019 (COVID-19), nucleoside drugs have once again received widespread …

Remdesivir was shown to inhibit RNA-dependent RNA-polymerases (RdRp) from distinct
viral families such as from Filoviridae (Ebola) and Coronaviridae (SARS-CoV, SARS-CoV-2 …

The search for new drugs has been greatly accelerated by the emergence of new viruses
and drug-resistant strains of known pathogens. Nucleoside analogues (NAs) are a …

Zika virus (ZIKV) belongs to the positive-sense single-stranded RNA-containing Flaviviridae
family. Its recent outbreak and association with human diseases (eg neurological disorders) …