Karl Lashley began the search for the engram nearly seventy years ago. In the time since,
much has been learned but divisions remain. In the contemporary neurobiology of learning …

The acquisition and execution of motor skills are mediated by a distributed motor network,
spanning cortical and subcortical brain areas. The sensorimotor striatum is an important cog …

How can short-lived molecules selectively maintain the potentiation of activated synapses to
sustain long-term memory? Here, we find kidney and brain expressed adaptor protein …

Normal neural circuits and functions depend on proper neuronal differentiation, migration,
synaptic plasticity, and maintenance. Abnormalities in these processes underlie various …

The zeta inhibitory peptide (ZIP) interferes with memory maintenance and long-term
potentiation (LTP) when administered to mice. However, mice lacking its putative target …

In “Criteria for identifying the molecular basis of the engram (CaMKII, PKMζ),” Lisman
proposes that elucidating the mechanism of LTP maintenance is key to understanding …

Long-term memories are thought to be stored in neurones and synapses that undergo
physical changes, such as long-term potentiation (LTP), and these changes can be …

The persistence of newly acquired memories is supported by the activity of PKMζ, an
atypical isoform of protein kinase C (PKC). Whether the activity of conventional and atypical …

The burgeoning field of neuroepigenetics has introduced chromatin modification as an
important interface between experience and brain function. For example, epigenetic …

Memory allows organisms to predict future events based on their prior sampling of the world.
Rather than faithfully encoding each detail of related episodes, the brain is thought to …