Adipose tissue, colloquially known as" fat," is an extraordinarily flexible and heterogeneous
organ. While historically viewed as a passive site for energy storage, we now appreciate that …

Obesity is a chronic and progressive process affecting whole-body energy balance and is
associated with comorbidity development. In addition to increased fat mass, obesity induces …

Fibrosis in adipose tissue is a major driver of obesity-related metabolic dysregulation. It is
characterized by an overaccumulation of extracellular matrix (ECM) during unhealthy …

Obesity and diabetes are established comorbidities for COVID-19. Adipose tissue
demonstrates high expression of ACE2 which SARS-CoV-2 exploits to enter host cells. This …

Prevention and treatment of non-communicable diseases (NCDs), including cardiovascular
disease, diabetes, obesity, cancer, Alzheimer's and Parkinson's disease, arthritis, non …

Insulin sensitivity progressively declines with age. Currently, the mechanism underlying age-
associated insulin resistance remains unknown. Here, we identify membrane-bound matrix …

Fibrosis of visceral organs such as the lungs, heart, kidneys and liver remains a major cause
of morbidity and mortality and is also associated with many other disorders, including cancer …

Lymphedema and lipedema are complex diseases. While the external presentation of
swollen legs in lower-extremity lymphedema and lipedema appear similar, current …

GDNF-family receptor a-like (GFRAL) has been identified as the cognate receptor of
growth/differentiation factor 15 (GDF15/MIC-1), considered a key signaling axis in energy …

Obesity causes extracellular matrix (ECM) remodelling which can develop into serious
pathology and fibrosis, having metabolic effects in insulin-sensitive tissues. The ECM …