The c-Jun N-terminal kinase 3 (JNK3) is the JNK isoform mainly expressed in the brain. It is
the most responsive to many stress stimuli in the central nervous system from ischemia to Aβ …

Kinases are an intensively studied drug target class in current pharmacological research as
evidenced by the large number of kinase inhibitors being assessed in clinical trials. Kinase …

Traditional medicines contain natural products (NPs) as main ingredient which always give
new direction and paths to develop new advanced medicines. In the COVID-19 pandemic …

Fluoxastrobin (FLUO), one of the best-selling strobilurin fungicides, could prevent fungal
diseases from oilseed crops, fruits, grains, and vegetables. The widespread use of FLUO …

Alzheimer's Disease (AD) is becoming more prevalent as the population lives longer. For
individuals over 60 years of age, the prevalence of AD is estimated at 40.19% across the …

Biochar-derived dissolved organic matter (DOM) contains toxic substances that are first
released into the soil after biochar application. However, the ecological risks of biochar …

c-Jun-N-terminal kinase (JNK) activity plays a critical role in modulating cell death, which
depends on the level and duration of JNK activation. The kinase cascade from MAPkinase …

JNK is a protein kinase, which induces transactivation of c-jun. The three isoforms of JNK,
JNK1, JNK2, and JNK3, are encoded by three distinct genes. JNK1 and JNK2 are expressed …

Metabolic Syndrome is a multifactorial disease associated with increased risk of
cardiovascular disorders, type 2 diabetes mellitus, fatty liver disease, etc. Various stress …

Diseases related to impaired blood flow such as peripheral artery disease (PAD) impact
nearly 10 million people in the United States alone, yet patients with clinical manifestations …