Fluorinated triazoles as privileged potential candidates in drug development—focusing on their biological and pharmaceutical properties

I Ullah, M Ilyas, M Omer, M Alamzeb, Adnan… - Frontiers in …, 2022 - frontiersin.org
Fluorinated heterocycles have attracted extensive attention not only in organic synthesis but
also in pharmaceutical and medicinal sciences due to their enhanced biological activities …

Different Synthetic Methods for the Preparation of Triazolopyrimidines and Their Biological Profile

A Hibot, A Oumessaoud, A Hafid, M Khouili… - …, 2023 - Wiley Online Library
One or more nitrogen‐containing molecules constitute an important class of heterocyclic
compounds in organic synthesis, due to their reactivity and their presence in many …

Synthesis of a new series of pyrazolo [1, 5-a] pyrimidines as CDK2 inhibitors and anti-leukemia

SJ Almehmadi, AMR Alsaedi, MF Harras… - Bioorganic …, 2021 - Elsevier
Based on the structural study of previously known CDK2 inhibitors, a new series of pyrazolo
[1, 5-a] pyrimidine derivatives was designed and synthesized. The target compounds were …

[HTML][HTML] Designing of novel nano-sized coordination compounds based on Spinacia oleracea extract: Synthesis, structural characterization, molecular docking …

S Hosny, MR Shehata, SA Aly, AH Alsehli… - Inorganic Chemistry …, 2024 - Elsevier
A novel series of nano-sized metal chelates of 1-((E)-(2-mercaptophenylimino) methyl)
naphthalen-2-ol (H 2 L) Azo-methine ligand with Fe (III), Ni (II) and Ag (II) were prepared and …

Synthesis, characterization, antibacterial, antifungal and anticorrosion activities of 1, 2, 4-triazolo [1, 5-a] quinazolinone

W Ettahiri, R Salim, M Adardour, E Ech-Chihbi… - Molecules, 2023 - mdpi.com
The synthesis of 5, 6, 7, 8-tetrahydro-[1, 2, 4] triazolo [5, 1-b] quinazolin-9 (4H)-one (THTQ),
a potentially biologically active compound, was pursued, and its structure was determined …

[HTML][HTML] Fluorinated azole anticancer drugs: Synthesis, elaborated structure elucidation and docking studies

AMR Alsaedi, TA Farghaly, MR Shaaban - Arabian Journal of Chemistry, 2022 - Elsevier
The present article deals with the synthesis of novel nano-sized fluorinated thiazoles and
studying their anticancer potentiality. The targeted azoles could be accessed via trifluoro …

Design, Synthesis, antimicrobial screening and molecular modeling of novel 6, 7 dimethylquinoxalin-2 (1H)-one and thiazole derivatives targeting DNA gyrase …

RM Alqurashi, TA Farghaly, R Sabour… - Bioorganic …, 2023 - Elsevier
Abstract New 6, 7-dimethylquinoxalin-2 (1H)-one and hydrazineylidene thiazol-4-one
derivatives were synthesized, and evaluated for their in vitro antimicrobial activity. The …

VEGFR2 and hepatocellular carcinoma inhibitory activities of trisubstituted triazole derivatives

AMR Alsaedi, SJ Almehmadi, TA Farghaly… - Journal of Molecular …, 2022 - Elsevier
The vascular endothelial growth factor receptor 2 (VEGFR2) is considered as a significant
target for inhibition in the discovery of novel molecules with anti-proliferative activity. Here …

Synthesis, Anticancer Activity, Pharmacokinetics, and Docking Study of Some New Heterocycles Linked Indole Moiety

SF Mohamed, DH Elnaggar, MA Elsayed… - Polycyclic Aromatic …, 2023 - Taylor & Francis
A novel series of five or six new nitrogenated heterocyclic compounds were obtained by
reacting a chalcone derivative of 3-acetylindole with various reagents such as malononitrile …

[PDF][PDF] Synthesis and Evaluation of Bioactivity of 6-[(2-Pyridinyloxy)](benzo) imidazo [2, 1-b][1, 3] thiazine derivatives

L Saliyeva, N Slyvka, S Holota… - … Res Appl Chem, 2022 - biointerfaceresearch.com
A series of new 6-[(pyridine-2-yl) oxy]-6, 7-dihydro-5H-imidazo [2, 1-b] thiazines 4a-l and
their benzoannelated derivatives 4m-r was synthesized by the reaction between 3-hydroxy …