[HTML][HTML] Mechanisms of programmed DNA lesions and genomic instability in the immune system
Chromosomal translocations involving antigen receptor loci are common in lymphoid
malignancies. Translocations require DNA double-strand breaks (DSBs) at two …
malignancies. Translocations require DNA double-strand breaks (DSBs) at two …
Mechanism and regulation of class switch recombination
J Stavnezer, JEJ Guikema, CE Schrader - Annu. Rev. Immunol., 2008 - annualreviews.org
Antibody class switching occurs in mature B cells in response to antigen stimulation and
costimulatory signals. It occurs by a unique type of intrachromosomal deletional …
costimulatory signals. It occurs by a unique type of intrachromosomal deletional …
[HTML][HTML] 53BP1 inhibits homologous recombination in Brca1-deficient cells by blocking resection of DNA breaks
SF Bunting, E Callén, N Wong, HT Chen, F Polato… - Cell, 2010 - cell.com
Defective DNA repair by homologous recombination (HR) is thought to be a major
contributor to tumorigenesis in individuals carrying Brca1 mutations. Here, we show that …
contributor to tumorigenesis in individuals carrying Brca1 mutations. Here, we show that …
53BP1 nuclear bodies form around DNA lesions generated by mitotic transmission of chromosomes under replication stress
C Lukas, V Savic, S Bekker-Jensen, C Doil… - Nature cell …, 2011 - nature.com
Completion of genome duplication is challenged by structural and topological barriers that
impede progression of replication forks. Although this can seriously undermine genome …
impede progression of replication forks. Although this can seriously undermine genome …
DNA breaks and end resection measured genome-wide by end sequencing
DNA double-strand breaks (DSBs) arise during physiological transcription, DNA replication,
and antigen receptor diversification. Mistargeting or misprocessing of DSBs can result in …
and antigen receptor diversification. Mistargeting or misprocessing of DSBs can result in …
Aggressive lymphomas
G Lenz, LM Staudt - New England Journal of Medicine, 2010 - Mass Medical Soc
This review summarizes recent evidence concerning molecular changes in the commonest
type of lymphoma, diffuse large-B-cell lymphoma. Detailed studies have revealed three …
type of lymphoma, diffuse large-B-cell lymphoma. Detailed studies have revealed three …
Rif1 prevents resection of DNA breaks and promotes immunoglobulin class switching
M Di Virgilio, E Callen, A Yamane, W Zhang… - Science, 2013 - science.org
DNA double-strand breaks (DSBs) represent a threat to the genome because they can lead
to the loss of genetic information and chromosome rearrangements. The DNA repair protein …
to the loss of genetic information and chromosome rearrangements. The DNA repair protein …
[HTML][HTML] Identification of early replicating fragile sites that contribute to genome instability
JH Barlow, RB Faryabi, E Callén, N Wong… - Cell, 2013 - cell.com
DNA double-strand breaks (DSBs) in B lymphocytes arise stochastically during replication or
as a result of targeted DNA damage by activation-induced cytidine deaminase (AID). Here …
as a result of targeted DNA damage by activation-induced cytidine deaminase (AID). Here …
53BP1 mediates productive and mutagenic DNA repair through distinct phosphoprotein interactions
E Callen, M Di Virgilio, MJ Kruhlak, M Nieto-Soler… - Cell, 2013 - cell.com
The DNA damage response (DDR) protein 53BP1 protects DNA ends from excessive
resection in G1, and thereby favors repair by nonhomologous end-joining (NHEJ) as …
resection in G1, and thereby favors repair by nonhomologous end-joining (NHEJ) as …
A chromatin-wide transition to H4K20 monomethylation impairs genome integrity and programmed DNA rearrangements in the mouse
G Schotta, R Sengupta, S Kubicek, S Malin… - Genes & …, 2008 - genesdev.cshlp.org
H4K20 methylation is a broad chromatin modification that has been linked with diverse
epigenetic functions. Several enzymes target H4K20 methylation, consistent with distinct …
epigenetic functions. Several enzymes target H4K20 methylation, consistent with distinct …