Essential oils and terpenic compounds as potential hits for drugs against amitochondriate protists

SA Menezes, T Tasca - Tropical Medicine and Infectious Disease, 2023 - mdpi.com
The human anaerobic or microaerophilic protists Giardia duodenalis, Entamoeba histolytica,
and Trichomonas vaginalis are classified as amitochondriate parasites, a group of …

Target analysis, occurrence and cytotoxicity of halogenated polyhydroxyphenols as emerging disinfection byproducts in drinking water

Z Zhang, S Hu, G Sun, W Wang - Water Research, 2024 - Elsevier
Halogenated aromatic disinfection byproducts (DBPs) in drinking water, such as
halogenated phenols, have received widespread attention due to their high toxicity and …

Recent progress on the discovery of antiamoebic agents

F Hayat, A Azam, D Shin - Bioorganic & Medicinal Chemistry Letters, 2016 - Elsevier
A large number of protozoans infect humans but Entamoeba histolytica is the only organism
responsible for causing amoebiasis, a deadly disease after malaria. Numerous heterocycle …

m-CPBA Mediated Metal Free, Rapid Oxidation of Aliphatic Amines to Oximes

VV Patil, EM Gayakwad… - The Journal of Organic …, 2016 - ACS Publications
An efficient, rapid oxidation of various aliphatic amines to oximes using m-CPBA as an
oxidant in ethyl acetate is described. High conversion (100%) with> 90% oxime selectivity is …

Synthesis and Biological Evaluation of Benzo[b]thiophene Acylhydrazones as Antimicrobial Agents against Multidrug-Resistant Staphylococcus aureus

T Barbier, A Barbry, J Magand, C Badiou, F Davy… - Biomolecules, 2022 - mdpi.com
The benzo [b] thiophene nucleus and the acylhydrazone functional group were combined to
prepare three new series of compounds for screening against Staphylococcus aureus. The …

Synthesis, characterization and structure optimization of a series of thiazolidinone derivatives as Entamoeba histolytica inhibitors

M Mushtaque, F Avecilla, A Azam - European journal of medicinal chemistry, 2012 - Elsevier
A series of thiazolidinone derivatives were synthesized by sodium acetate assisted
cyclization of 1-isobutyl-3-phenylthiourea with chloroacetic acid followed by the piperidine …

Feedstock chemical dichloromethane as the C1 source for the chemoselective multicomponent synthesis of valuable 1, 4, 2-dioxazoles

MJ Xie, X Li, XX Li, LH Wen, SL Xie… - Communications …, 2024 - nature.com
The development of mild and practical strategies to produce value-added fine chemicals
directly from inexpensive and readily available commodity chemicals is actively pursued by …

Gold-Catalyzed [4+ 1] Heterocyclization of Hydroxamic Acid and Nonactivated Alkyne: A Protocol to Construct 5-Methyl-1, 4, 2-dioxazole

XL He, XR Ma, N Yan, XW Zhang - The Journal of Organic …, 2022 - ACS Publications
A novel gold-catalyzed [4+ 1] heterocyclization of nonactivated alkyne and hydroxamic acid
is developed for the regiospecific synthesis of 5-methyl-1, 4, 2-dioxazole, which is an …

Evaluation of Substituted 1, 2, 3‐Dithiazoles as Inhibitors of the Feline Immunodeficiency Virus (FIV) Nucleocapsid Protein via a Proposed Zinc Ejection Mechanism

CRM Asquith, LS Konstantinova, T Laitinen… - …, 2016 - Wiley Online Library
A diverse library of 5‐thieno‐, 5‐oxo‐, and 5‐imino‐1, 2, 3‐dithiazole derivatives was
synthesized and evaluated for efficacy against the feline immunodeficiency virus (FIV) as a …

Synthesis, evaluation and docking studies on steroidal pyrazolones as anticancer and antimicrobial agents

Shamsuzzaman, A Mashrai, A Ahmad, AM Dar… - Medicinal chemistry …, 2014 - Springer
A series of new steroidal pyrazolones have been synthesized, characterised and evaluated
for their in vitro anticancer activity. They were tested against five cancer (SW480, HepG2 …