Autophagy is a fundamental cellular process that eliminates molecules and subcellular
elements, including nucleic acids, proteins, lipids and organelles, via lysosome-mediated …

Autophagy is a versatile degradation system for maintaining cellular homeostasis whereby
cytosolic materials are sequestered in a double-membrane autophagosome and …

The major innate immune cell types involved in tuberculosis (TB) infection are
macrophages, dendritic cells (DCs), neutrophils and natural killer (NK) cells. These immune …

Tuberculosis (TB) caused by the bacterial pathogen Mycobacterium tuberculosis (Mtb)
remains one of the deadliest infectious diseases with over a billion deaths in the past 200 …

Cytosolic DNA is an indicator of pathogen invasion or DNA damage. The cytosolic DNA
sensor cyclic guanosine monophosphate-adenosine monophosphate (cGAMP) synthase …

Lysosomes are catabolic organelles that contribute to the degradation of intracellular
constituents through autophagy and of extracellular components through endocytosis …

Detection of foreign nucleic acids is an important strategy for innate immune recognition of
pathogens. In vertebrates, pathogen-derived DNA is sensed in the cytosol by cGAS, which …

Traditional drug discovery focuses on identifying direct inhibitors of target proteins. This
typically relies on a measurable biochemical readout and accessible binding sites whose …

Epithelial tissues cover most of the external and internal surfaces of the body and its organs.
Inevitably, these tissues serve as first line of defence against inorganic, organic, and …

Tuberculosis (TB), which is primarily caused by the major etiologic agent Mycobacterium
tuberculosis (Mtb), remains a serious infectious disease worldwide. Recently, much effort …