Connectome-based modelling of neurodegenerative diseases: towards precision medicine and mechanistic insight

JW Vogel, N Corriveau-Lecavalier… - Nature Reviews …, 2023 - nature.com
Neurodegenerative diseases are the most common cause of dementia. Although their
underlying molecular pathologies have been identified, there is substantial heterogeneity in …

Stress and adolescence: Vulnerability and opportunity during a sensitive window of development

LM Sisk, DG Gee - Current Opinion in Psychology, 2022 - Elsevier
Adolescence is a period of dynamic change across multiple systems. Concurrent maturation
of neural, biological, and psychosocial functioning renders adolescence a time of …

[HTML][HTML] Brain charts for the human lifespan

RAI Bethlehem, J Seidlitz, SR White, JW Vogel… - Nature, 2022 - nature.com
Over the past few decades, neuroimaging has become a ubiquitous tool in basic research
and clinical studies of the human brain. However, no reference standards currently exist to …

Human brain effects of DMT assessed via EEG-fMRI

C Timmermann, L Roseman… - Proceedings of the …, 2023 - National Acad Sciences
Psychedelics have attracted medical interest, but their effects on human brain function are
incompletely understood. In a comprehensive, within-subjects, placebo-controlled design …

Neuromaps: structural and functional interpretation of brain maps

RD Markello, JY Hansen, ZQ Liu, V Bazinet, G Shafiei… - Nature …, 2022 - nature.com
Imaging technologies are increasingly used to generate high-resolution reference maps of
brain structure and function. Comparing experimentally generated maps to these reference …

[HTML][HTML] Human prefrontal cortex gene regulatory dynamics from gestation to adulthood at single-cell resolution

CA Herring, RK Simmons, S Freytag, D Poppe… - Cell, 2022 - cell.com
Human brain development is underpinned by cellular and molecular reconfigurations
continuing into the third decade of life. To reveal cell dynamics orchestrating neural …

Intrinsic activity development unfolds along a sensorimotor–association cortical axis in youth

VJ Sydnor, B Larsen, J Seidlitz, A Adebimpe… - Nature …, 2023 - nature.com
Animal studies of neurodevelopment have shown that recordings of intrinsic cortical activity
evolve from synchronized and high amplitude to sparse and low amplitude as plasticity …

Developmental mechanisms underlying the evolution of human cortical circuits

P Vanderhaeghen, F Polleux - Nature Reviews Neuroscience, 2023 - nature.com
The brain of modern humans has evolved remarkable computational abilities that enable
higher cognitive functions. These capacities are tightly linked to an increase in the size and …

Hierarchical functional system development supports executive function

AS Keller, VJ Sydnor, A Pines, DA Fair… - Trends in cognitive …, 2023 - cell.com
In this perspective, we describe how developmental improvements in youth executive
function (EF) are supported by hierarchically organized maturational changes in functional …

Coordinated cortical thickness alterations across six neurodevelopmental and psychiatric disorders

MD Hettwer, S Larivière, BY Park… - Nature …, 2022 - nature.com
Neuropsychiatric disorders are increasingly conceptualized as overlapping spectra sharing
multi-level neurobiological alterations. However, whether transdiagnostic cortical alterations …