Oxidative stress and reactive oxygen species: a review of their role in ocular disease

L Ung, U Pattamatta, N Carnt… - Clinical …, 2017 - portlandpress.com
For many years, oxidative stress arising from the ubiquitous production of reactive oxygen
species (ROS) has been implicated in the pathogenesis of various eye diseases. While …

Role of oxidative stress in ocular diseases: a balancing act

DY Shu, S Chaudhary, KS Cho, A Lennikov, WP Miller… - Metabolites, 2023 - mdpi.com
Redox homeostasis is a delicate balancing act of maintaining appropriate levels of
antioxidant defense mechanisms and reactive oxidizing oxygen and nitrogen species. Any …

Evolution of oxidative stress, inflammation and neovascularization in the choroid and retina in a subretinal lipid induced age-related macular degeneration model

SY Kim, SP Kambhampati, IA Bhutto, DS McLeod… - Experimental eye …, 2021 - Elsevier
Oxidative stress, inflammation and neovascularization are the key pathological events that
are implicated in human age-related macular degeneration (AMD). There are a limited …

Acrolein: a potential mediator of oxidative damage in diabetic retinopathy

M Alfarhan, E Jafari, SP Narayanan - Biomolecules, 2020 - mdpi.com
Diabetic retinopathy (DR) is the leading cause of vision loss among working-age adults.
Extensive evidences have documented that oxidative stress mediates a critical role in the …

Adipose‐Derived Mesenchymal Stem Cells Migrate and Rescue RPE in the Setting of Oxidative Stress

A Barzelay, S Weisthal Algor, A Niztan… - Stem Cells …, 2018 - Wiley Online Library
Oxidative stress leads to the degeneration of retinal pigment epithelial (RPE) and
photoreceptor cells. We evaluated the potential of adipose‐derived mesenchymal stem cells …

Protective effect of hydrogen on sodium iodate-induced age-related macular degeneration in mice

Y Liu, R Li, J Xie, J Hu, X Huang, F Ren… - Frontiers in aging …, 2018 - frontiersin.org
Oxidative stress is one of the main causes of AMD. Hydrogen has anti-oxidative stress and
apoptotic effects on retinal injury. However, the effect of hydrogen on AMD is not clear. In this …

Oxidative stress, diabetic retinopathy, and superoxide dismutase 3

L Ikelle, MI Naash, MR Al-Ubaidi - Retinal Degenerative Diseases …, 2019 - Springer
Diabetic retinopathy (DR) is a multifaceted disease, combining the deleterious effects of
hyperglycemia and the propensity for accumulation of reactive oxygen species. Studies …

Modulation of α‐adrenoceptor signalling protects photoreceptors after retinal detachment by inhibiting oxidative stress and inflammation

T Li, S Yang, X She, Q Yan, P Zhang… - British journal of …, 2019 - Wiley Online Library
Background and Purpose Currently available treatments do not halt progression of
photoreceptor death and subsequent visual impairment related to retinal detachment (RD) …

Protection effect of lutein-loaded Pickering emulsion prepared via ultrasound-assisted Maillard reaction conjugates on dry age-related macular degeneration

K Liu, Y Li, X Zhong, Y Hou, S Fei, E Chen, M Tan - Food & Function, 2024 - pubs.rsc.org
Age-related macular degeneration (AMD) is a prominent cause of vision loss among the
elderly, and the treatment options for dry AMD (dAMD) are severely limited. Lutein has a …

The urokinase‐type plasminogen activator system as drug target in retinitis pigmentosa: New pre‐clinical evidence in the rd10 mouse model

M Cammalleri, M Dal Monte, F Locri… - Journal of Cellular …, 2019 - Wiley Online Library
Retinitis pigmentosa (RP) is characterized by progressive loss of vision due to photoreceptor
degeneration leading to secondary inflammation. The urokinase‐type plasminogen activator …