Directed evolution: methodologies and applications

Y Wang, P Xue, M Cao, T Yu, ST Lane… - Chemical reviews, 2021 - ACS Publications
Directed evolution aims to expedite the natural evolution process of biological molecules
and systems in a test tube through iterative rounds of gene diversifications and library …

The dawn of a new era: targeting the “undruggables” with antibody-based therapeutics

L Qian, X Lin, X Gao, RU Khan, JY Liao, S Du… - Chemical …, 2023 - ACS Publications
The high selectivity and affinity of antibodies toward their antigens have made them a highly
valuable tool in disease therapy, diagnosis, and basic research. A plethora of chemical and …

Reducing affinity as a strategy to boost immunomodulatory antibody agonism

X Yu, CM Orr, HTC Chan, S James, CA Penfold, J Kim… - Nature, 2023 - nature.com
Antibody responses during infection and vaccination typically undergo affinity maturation to
achieve high-affinity binding for efficient neutralization of pathogens,. Similarly, high affinity …

Non-invasive delivery strategies for biologics

AC Anselmo, Y Gokarn, S Mitragotri - Nature Reviews Drug Discovery, 2019 - nature.com
Biologics now constitute a significant element of available medical treatments. Owing to their
clinical and commercial success, biologics are a rapidly growing class and have become a …

Immunomodulation—a general review of the current state-of-the-art and new therapeutic strategies for targeting the immune system

M Strzelec, J Detka, P Mieszczak… - Frontiers in …, 2023 - frontiersin.org
In recent years, there has been a tremendous development of biotechnological,
pharmacological, and medical techniques which can be implemented in the functional …

Human immunology and immunotherapy: main achievements and challenges

J Varadé, S Magadán… - Cellular & Molecular …, 2021 - nature.com
The immune system is a fascinating world of cells, soluble factors, interacting cells, and
tissues, all of which are interconnected. The highly complex nature of the immune system …

Alternative therapeutic strategies to treat antibiotic-resistant pathogens

CR MacNair, ST Rutherford, MW Tan - Nature Reviews Microbiology, 2024 - nature.com
Resistance threatens to render antibiotics—which are essential for modern medicine—
ineffective, thus posing a threat to human health. The discovery of novel classes of …

Rekindling RNAi therapy: materials design requirements for in vivo siRNA delivery

B Kim, JH Park, MJ Sailor - Advanced materials, 2019 - Wiley Online Library
With the recent FDA approval of the first siRNA‐derived therapeutic, RNA interference
(RNAi)‐mediated gene therapy is undergoing a transition from research to the clinical …

[HTML][HTML] IgG glycans in health and disease: Prediction, intervention, prognosis, and therapy

S Shkunnikova, A Mijakovac, L Sironic, M Hanic… - Biotechnology …, 2023 - Elsevier
Immunoglobulin (IgG) glycosylation is a complex enzymatically controlled process, essential
for the structure and function of IgG. IgG glycome is relatively stable in the state of …

Nanocarriers for the delivery of medical, veterinary, and agricultural active ingredients

PL Chariou, OA Ortega-Rivera, NF Steinmetz - Acs Nano, 2020 - ACS Publications
Nanocarrier-based delivery systems can be used to increase the safety and efficacy of active
ingredients in medical, veterinary, or agricultural applications, particularly when such …