Myofibroblasts are the construction workers of wound healing and repair damaged tissues
by producing and organizing collagen/extracellular matrix (ECM) into scar tissue. Scar tissue …

Tumors are characterized by extracellular matrix (ECM) deposition, remodeling, and cross-
linking that drive fibrosis to stiffen the stroma and promote malignancy. The stiffened stroma …

Organ fibrosis is a lethal outcome of autoimmune rheumatic diseases such as systemic
sclerosis. Myofibroblasts are scar-forming cells that are ultimately responsible for the …

Fibroblasts are a dynamic cell type that achieve selective differentiated states to mediate
acute wound healing and long-term tissue remodeling with scarring. With myocardial …

Myofibroblasts are contractile, α-smooth muscle actin-positive cells with multiple roles in
pathophysiological processes. Myofibroblasts mediate wound contractions, but their …

Multipotent stromal cells (MSCs) are vital for development, maintenance, function, and
regeneration of most tissues. They can differentiate along multiple connective lineages, but …

Non-healing chronic wounds present a major biological, psychological, social, and financial
burden on both individual patients and the broader health system. Pathologically extensive …

Biomaterial‐mediated inflammation and fibrosis remain a prominent challenge in designing
materials to support tissue repair and regeneration. Despite the many biomaterial …

Scarring is part of the normal healing response to tissue injury in all organs and required to
rapidly repair acute damages, mostly with extracellular matrix. A variety of different cells are …

(Myo) fibroblasts are key players for maintaining skin homeostasis and for orchestrating
physiological tissue repair.(Myo) fibroblasts are embedded in a sophisticated extracellular …