This article reviews the discovery of PCSK9, its structure–function characteristics, and its
presently known and proposed novel biological functions. The major critical function of …

Lassa virus (LASV) is endemic in the rodent populations of Sierra Leone, Nigeria and other
countries in West Africa. Spillover to humans occurs frequently and results in Lassa fever, a …

The mammalian proprotein convertases constitute a family of nine secretory serine
proteases that are related to bacterial subtilisin and yeast kexin. Seven of these (proprotein …

Crimean–Congo hemorrhagic fever (CCHF) is a tick-borne disease caused by the arbovirus
Crimean–Congo hemorrhagic fever virus (CCHFV), which is a member of the Nairovirus …

Glycans are among the most important cell molecular components. However, given their
structural diversity, their functions have not been fully explored. Glycosylation is a vital post …

Lujo virus (LUJV), a new member of the family Arenaviridae and the first hemorrhagic fever–
associated arenavirus from the Old World discovered in three decades, was isolated in …

Four families of enveloped RNA viruses, filoviruses, flaviviruses, arenaviruses, and
bunyaviruses, cause hemorrhagic fevers. These viruses are maintained in specific natural …

Summary Guanylate-binding protein (GBP) 5 is an interferon (IFN)-inducible cellular factor
reducing HIV-1 infectivity by an incompletely understood mechanism. Here, we show that …

Replication-competent recombinant vesicular stomatitis viruses (rVSVs) expressing the type
I transmembrane glycoproteins and selected soluble glycoproteins of several viral …

Until recently, members of the monogeneric family Arenaviridae (arenaviruses) have been
known to infect only muroid rodents and, in one case, possibly phyllostomid bats. The …