[HTML][HTML] mTOR substrate phosphorylation in growth control
The target of rapamycin (TOR), discovered 30 years ago, is a highly conserved
serine/threonine protein kinase that plays a central role in regulating cell growth and …
serine/threonine protein kinase that plays a central role in regulating cell growth and …
Obesity as a risk factor for dementia and Alzheimer's disease: the role of leptin
JA Flores-Cordero, A Pérez-Pérez… - International journal of …, 2022 - mdpi.com
Obesity is a growing worldwide health problem, affecting many people due to excessive
saturated fat consumption, lack of exercise, or a sedentary lifestyle. Leptin is an adipokine …
saturated fat consumption, lack of exercise, or a sedentary lifestyle. Leptin is an adipokine …
mTOR in brain physiology and pathologies
J Bockaert, P Marin - Physiological reviews, 2015 - journals.physiology.org
TOR (target of rapamycin) and its mammalian ortholog mTOR have been discovered in an
effort to understand the mechanisms of action of the immunosuppressant drug rapamycin …
effort to understand the mechanisms of action of the immunosuppressant drug rapamycin …
Targeting autophagy for the treatment of Alzheimer's disease: challenges and opportunities
J Liu, L Li - Frontiers in molecular neuroscience, 2019 - frontiersin.org
Alzheimer's disease (AD) is the most common type of dementia which characterized by a
progressive loss of memory and cognitive function due to degeneration of synapses and …
progressive loss of memory and cognitive function due to degeneration of synapses and …
Autophagic and lysosomal defects in human tauopathies: analysis of post-mortem brain from patients with familial Alzheimer disease, corticobasal degeneration and …
Introduction The accumulation of insoluble proteins within neurons and glia cells is a
pathological hallmark of several neurodegenerative diseases. Abnormal aggregation of the …
pathological hallmark of several neurodegenerative diseases. Abnormal aggregation of the …
Diabetic retinopathy: loss of neuroretinal adaptation to the diabetic metabolic environment
SF Abcouwer, TW Gardner - Annals of the New York Academy …, 2014 - Wiley Online Library
Diabetic retinopathy (DR) impairs vision of patients with type 1 and type 2 diabetes,
associated with vascular dysfunction and occlusion, retinal edema, hemorrhage, and …
associated with vascular dysfunction and occlusion, retinal edema, hemorrhage, and …
Abnormal serine phosphorylation of insulin receptor substrate 1 is associated with tau pathology in Alzheimer's disease and tauopathies
Neuronal insulin signaling abnormalities have been associated with Alzheimer's disease
(AD). However, the specificity of this association and its underlying mechanisms have been …
(AD). However, the specificity of this association and its underlying mechanisms have been …
Zinc in cognitive impairment and aging
R Sun, J Wang, J Feng, B Cao - Biomolecules, 2022 - mdpi.com
Zinc, an essential micronutrient for life, was first discovered in 1869 and later found to be
indispensable for the normal development of plants and for the normal growth of rats and …
indispensable for the normal development of plants and for the normal growth of rats and …
Genetic reduction of mammalian target of rapamycin ameliorates Alzheimer's disease-like cognitive and pathological deficits by restoring hippocampal gene …
Elevated mammalian target of rapamycin (mTOR) signaling has been found in Alzheimer's
disease (AD) patients and is linked to diabetes and aging, two known risk factors for AD …
disease (AD) patients and is linked to diabetes and aging, two known risk factors for AD …
mTOR signaling as a molecular target for the alleviation of Alzheimer's disease pathogenesis
Mechanistic/mammalian target of rapamycin (mTOR) belongs to the phosphatidylinositol
kinase-related kinase (PIKK) family. mTOR signaling is required for the commencement of …
kinase-related kinase (PIKK) family. mTOR signaling is required for the commencement of …