Hemostasis and thrombosis are believed to be so intricately linked that any strategies that
reduce thrombosis will have an inevitable impact on hemostasis. Consequently, bleeding is …

Since the emergence of regenerative medicine and tissue engineering more than half a
century ago, one obstacle has persisted: the in vitro creation of large-scale vascular tissue (> …

Multiple mechanisms mediate thrombin generation and consequently the thrombin
concentration present during fibrin formation. First, the levels of pro-and anticoagulants …

Blood‐contacting medical devices, such as vascular grafts, stents, heart valves, and
catheters, are often used to treat cardiovascular diseases. Thrombus formation is a common …

Background Experimental data indicate that reducing factor XI levels attenuates thrombosis
without causing bleeding, but the role of factor XI in the prevention of postoperative venous …

Activation of the intrinsic pathway of coagulation contributes to the pathogenesis of arterial
and venous thrombosis. Critical insights into the involvement of intrinsic pathway factors …

The antiphospholipid syndrome is a prothrombotic disorder associated with autoantibodies.
It is associated with obstetrical complications (mainly spontaneous abortion) as well as …

Anticoagulants are the cornerstone for prevention and treatment of thrombosis but are not
completely effective, and concerns about the risk of bleeding continue to limit their uptake …

Platelets play a central role in thrombosis, hemostasis, and inflammation. We show that
activated platelets release inorganic polyphosphate (polyP), a polymer of 60–100 …

End-stage renal disease (ESRD) patients on chronic hemodialysis have repeated blood
exposure to artificial surfaces that can trigger clot formation within the hemodialysis circuit …