Applications of tandem mass spectrometry (MS/MS) in protein analysis for biomedical research

AN Neagu, M Jayathirtha, E Baxter, M Donnelly… - Molecules, 2022 - mdpi.com
Mass Spectrometry (MS) allows the analysis of proteins and peptides through a variety of
methods, such as Electrospray Ionization-Mass Spectrometry (ESI-MS) or Matrix-Assisted …

Molecular markers: a new paradigm in the prediction of sperm freezability

M Ďuračka, F Benko, E Tvrdá - International journal of molecular sciences, 2023 - mdpi.com
For decades now, sperm cryopreservation has been a pillar of assisted reproduction in
animals as well as humans. Nevertheless, the success of cryopreservation varies across …

T lymphocytes and testicular immunity: a new insight into immune regulation in testes

J Gong, Q Zeng, D Yu, YG Duan - International journal of molecular …, 2020 - mdpi.com
The immune privilege of the testes is necessary to prevent immune attacks to gamete-
specific antigens and paternal major histocompatibility complex (MHC) antigens, allowing …

Influence of risk factors for male infertility on sperm protein composition

M Bisconti, JF Simon, S Grassi, B Leroy… - International Journal of …, 2021 - mdpi.com
Male infertility is a common health problem that can be influenced by a host of lifestyle risk
factors such as environment, nutrition, smoking, stress, and endocrine disruptors. These …

Mitochondrial defects caused by PARL deficiency lead to arrested spermatogenesis and ferroptosis

E Radaelli, CA Assenmacher, J Verrelle, E Banerjee… - Elife, 2023 - elifesciences.org
Impaired spermatogenesis and male infertility are common manifestations associated with
mitochondrial diseases, yet the underlying mechanisms linking these conditions remain …

[HTML][HTML] Seminal exosomes–an important biological marker for various disorders and syndrome in human reproduction

AS Vickram, PS Srikumar, S Srinivasan… - Saudi journal of …, 2021 - Elsevier
Background Exosomes are nano-sized membrane vesicles, secreted by different types of
cells into the body's biological fluids. They are found in abundance in semen as compared to …

The human sperm basal body is a complex centrosome important for embryo preimplantation development

F Amargant, A Pujol, A Ferrer-Vaquer… - Molecular human …, 2021 - academic.oup.com
The mechanism of conversion of the human sperm basal body to a centrosome after
fertilization, and its role in supporting human early embryogenesis, has not been directly …

Comparative proteomics and phosphoproteomics analysis reveal the possible breed difference in yorkshire and duroc boar spermatozoa

Y Xu, Q Han, C Ma, Y Wang, P Zhang, C Li… - Frontiers in Cell and …, 2021 - frontiersin.org
Sperm cells are of unique elongated structure and function, the development of which is
tightly regulated by the existing proteins and the posttranslational modifications (PTM) of …

Membrane lipid replacement with nano-micelles in human sperm cryopreservation improves post-thaw function and acrosome protein integrity

M Hezavehei, M Sharafi, R Fathi, A Shahverdi… - Reproductive …, 2021 - Elsevier
Research question Membrane lipid replacement (MLR) of oxidized membrane lipids can
restore sperm cellular membrane functionality and help improve surface protein stability …

New horizons in human sperm selection for assisted reproduction

B Nixon, JE Schjenken, ND Burke… - Frontiers in …, 2023 - frontiersin.org
Male infertility is a commonly encountered pathology that is estimated to be a contributory
factor in approximately 50% of couples seeking recourse to assisted reproductive …