Patient-derived xenograft models in cancer therapy: technologies and applications
Patient-derived xenograft (PDX) models, in which tumor tissues from patients are implanted
into immunocompromised or humanized mice, have shown superiority in recapitulating the …
into immunocompromised or humanized mice, have shown superiority in recapitulating the …
Vitamin D and cancer: an historical overview of the epidemiology and mechanisms
This is a narrative review of the evidence supporting vitamin D's anticancer actions. The first
section reviews the findings from ecological studies of cancer with respect to indices of solar …
section reviews the findings from ecological studies of cancer with respect to indices of solar …
Discovery of cryptic allosteric sites using reversed allosteric communication by a combined computational and experimental strategy
Allostery, which is one of the most direct and efficient methods to fine-tune protein functions,
has gained increasing recognition in drug discovery. However, there are several challenges …
has gained increasing recognition in drug discovery. However, there are several challenges …
Emerging roles of SIRT6 in human diseases and its modulators
The biological functions of sirtuin 6 (SIRT6; eg, deacetylation, defatty‐acylation, and mono‐
ADP‐ribosylation) play a pivotal role in regulating lifespan and several fundamental …
ADP‐ribosylation) play a pivotal role in regulating lifespan and several fundamental …
[HTML][HTML] SIRT6 in aging, metabolism, inflammation and cardiovascular diseases
Z Guo, P Li, J Ge, H Li - Aging and disease, 2022 - ncbi.nlm.nih.gov
As an important NAD+-dependent enzyme, SIRT6 has received significant attention since its
discovery. In view of observations that SIRT6-deficient animals exhibit genomic instability …
discovery. In view of observations that SIRT6-deficient animals exhibit genomic instability …
Emerging therapeutic potential of SIRT6 modulators
Sirtuin 6 (SIRT6) is an NAD+-dependent protein deacylase and mono-ADP-
ribosyltransferase of the sirtuin family with a wide substrate specificity. In vitro and in vivo …
ribosyltransferase of the sirtuin family with a wide substrate specificity. In vitro and in vivo …
Novel 1, 4-dihydropyridines as specific binders and activators of SIRT3 impair cell viability and clonogenicity and downregulate hypoxia-induced targets in cancer …
The mitochondrial SIRT3 modulates several biological pathways such as cancer,
metabolism, and hypoxia-related diseases. Recently, we discovered new 1, 4 …
metabolism, and hypoxia-related diseases. Recently, we discovered new 1, 4 …
Sirtuin 6—a key regulator of hepatic lipid metabolism and liver Health
XC Dong - cells, 2023 - mdpi.com
Sirtuin 6 (SIRT6) is an NAD-dependent deacetylase/deacylase/mono-ADP
ribosyltransferase, a member of the sirtuin protein family. SIRT6 has been implicated in …
ribosyltransferase, a member of the sirtuin protein family. SIRT6 has been implicated in …
The two-faced role of SIRT6 in cancer
Simple Summary Cancer therapy relies on the employment of different strategies aimed at
inducing cancer cell death through different mechanisms, including DNA damage and …
inducing cancer cell death through different mechanisms, including DNA damage and …
Activation and inhibition of sirtuins: From bench to bedside
F Fiorentino, E Fabbrizi, A Mai… - Medicinal Research …, 2024 - Wiley Online Library
The sirtuin family comprises seven NAD+‐dependent enzymes which catalyze protein lysine
deacylation and mono ADP‐ribosylation. Sirtuins act as central regulators of genomic …
deacylation and mono ADP‐ribosylation. Sirtuins act as central regulators of genomic …