Molecular basis of cardioprotection: signal transduction in ischemic pre-, post-, and remote conditioning

G Heusch - Circulation research, 2015 - Am Heart Assoc
Reperfusion is mandatory to salvage ischemic myocardium from infarction, but reperfusion
per se contributes to injury and ultimate infarct size. Therefore, cardioprotection beyond that …

An overview of the molecular mechanisms associated with myocardial ischemic injury: state of the art and translational perspectives

L Schirone, M Forte, L D'Ambrosio, V Valenti… - Cells, 2022 - mdpi.com
Cardiovascular disease is the leading cause of death in western countries. Among
cardiovascular diseases, myocardial infarction represents a life-threatening condition …

Extracellular vesicles engineering by silicates-activated endothelial progenitor cells for myocardial infarction treatment in male mice

B Yu, H Li, Z Zhang, P Chen, L Wang, X Fan… - Nature …, 2023 - nature.com
Extracellular vesicles have shown good potential in disease treatments including ischemic
injury such as myocardial infarction. However, the efficient production of highly active …

Anti‐inflammatory therapies in myocardial infarction: failures, hopes and challenges

S Huang, NG Frangogiannis - British journal of pharmacology, 2018 - Wiley Online Library
In the infarcted heart, the damage‐associated molecular pattern proteins released by
necrotic cells trigger both myocardial and systemic inflammatory responses. Induction of …

Mesenchymal stem cell migration during bone formation and bone diseases therapy

P Su, Y Tian, C Yang, X Ma, X Wang, J Pei… - International journal of …, 2018 - mdpi.com
During bone modeling, remodeling, and bone fracture repair, mesenchymal stem cells
(MSCs) differentiate into chondrocyte or osteoblast to comply bone formation and …

Exosomes secreted by hiPSC-derived cardiac cells improve recovery from myocardial infarction in swine

L Gao, L Wang, Y Wei, P Krishnamurthy… - Science translational …, 2020 - science.org
Cell therapy treatment of myocardial infarction (MI) is mediated, in part, by exosomes
secreted from transplanted cells. Thus, we compared the efficacy of treatment with a mixture …

The CXCL12/CXCR4 chemokine ligand/receptor axis in cardiovascular disease

Y Döring, L Pawig, C Weber, H Noels - Frontiers in physiology, 2014 - frontiersin.org
The chemokine receptor CXCR4 and its ligand CXCL12 play an important homeostatic
function by mediating the homing of progenitor cells in the bone marrow and regulating their …

Left ventricular unloading before reperfusion promotes functional recovery after acute myocardial infarction

ML Esposito, Y Zhang, X Qiao, L Reyelt… - Journal of the American …, 2018 - jacc.org
Background: Heart failure after an acute myocardial infarction (AMI) is a major cause of
morbidity and mortality worldwide. We recently reported that activation of a transvalvular …

A unique collateral artery development program promotes neonatal heart regeneration

S Das, AB Goldstone, H Wang, J Farry, G D'Amato… - Cell, 2019 - cell.com
Collateral arteries are an uncommon vessel subtype that can provide alternate blood flow to
preserve tissue following vascular occlusion. Some patients with heart disease develop …

CXCL12/CXCR4 signal transduction in diseases and its molecular approaches in targeted-therapy

A Mousavi - Immunology Letters, 2020 - Elsevier
Chemokines are small molecules called “chemotactic cytokines” and regulate many
processes like leukocyte trafficking, homing of immune cells, maturation, cytoskeletal …