Clinicians understand that individual patients differ in their response to specific opioid
analgesics and that patients may require trials of several opioids before finding an agent that …

Opium, the dried juice of the seedpod of the opium poppy, has been used for the relief of
pain and suffering for several thousand years. Many opioid drugs are still derived from …

Cervical cancer is one of the gravest threats to women's lives. It is estimated that over a
million women worldwide currently have cervical cancer. Most of these women have not …

Use of chronic opioid therapy for chronic noncancer pain has increased substantially. The
American Pain Society and the American Academy of Pain Medicine commissioned a …

Opioid therapy for chronic pain has been popularized over the past few decades, and a
concern has arisen that the analgesic efficacy of opioids is not always maintained over …

Despite the increasing clinical use of transdermal buprenorphine, questions have persisted
about the possibility of a ceiling effect for analgesia, its combination with other μ‐opioid …

Clinical studies comparing the response and side effects of various opioids have not been
able to show robust differences between drugs. Hence, recommendations of the regulatory …

Background Many patients with lung cancer will develop symptoms related to their disease
process or the treatment they are receiving. These symptoms can be as debilitating as the …

Objectives: We aimed to examine the published literature on basic science explaining
pronociceptive opioid actions, and apply this knowledge to clinical observation. Methods …

Patients face difficult decisions about chemotherapy near the end of life. Such treatment
might prolong survival or reduce symptoms but cause adverse effects, prevent the patient …