We review the central tenets and neuroanatomical basis of the global neuronal workspace
(GNW) hypothesis, which attempts to account for the main scientific observations regarding …

Ketamine was introduced into clinical practice in the 1960s and continues to be both
clinically useful and scientifically fascinating. With considerably diverse molecular targets …

Over the past 50 years, ketamine has solidified its position in both human and veterinary
medicine as an important anesthetic with many uses. More recently, ketamine has been …

Background Consciousness-altering anesthetic agents disturb connectivity between brain
regions composing the resting-state consciousness networks (RSNs). The default mode …

Conscious access to sensory information is likely gated at an intermediate site between
primary sensory and transmodal association cortices, but the structure responsible remains …

The biological basis of consciousness is one of the most challenging and fundamental
questions in 21st century science. A related pursuit aims to identify the neural correlates and …

Abstract Editor's Perspective What We Already Know about This Topic Anesthesia-induced
loss of consciousness is paralleled by a disruption of frontoparietal functional correlation, as …

Leading neuroscientific theories posit a central role for the functional integration of cortical
areas in conscious states. Considerable evidence supporting this hypothesis is based on …

Ketamine, a molecule of many faces, has contributed immeasurably to numerous realms of
clinical practice and scientific inquiry. From anesthesia and analgesia to depression and …

There has been controversy regarding the precise mechanisms of anesthetic-induced
unconsciousness, with two salient approaches that have emerged within systems …