[HTML][HTML] Clinical significance and applications of oscillometry

DA Kaminsky, SJ Simpson, KI Berger… - European respiratory …, 2022 - Eur Respiratory Soc
Recently,“Technical standards for respiratory oscillometry” was published, which reviewed
the physiological basis of oscillometric measures and detailed the technical factors related …

Advances and recent developments in asthma in 2020

L Cevhertas, I Ogulur, DJ Maurer, D Burla, M Ding… - Allergy, 2020 - Wiley Online Library
In this review, we discuss recent publications on asthma and review the studies that have
reported on the different aspects of the prevalence, risk factors and prevention, mechanisms …

European Respiratory Society guidelines for the diagnosis of asthma in adults

R Louis, I Satia, I Ojanguren, F Schleich… - European …, 2022 - Eur Respiratory Soc
Although asthma is very common, affecting 5–10% of the population, the diagnosis of
asthma in adults remains a challenge in the real world, which results in both over-and under …

The role of small airway dysfunction in asthma control and exacerbations: a longitudinal, observational analysis using data from the ATLANTIS study

M Kraft, M Richardson, B Hallmark… - The Lancet …, 2022 - thelancet.com
Background Although small airway disease is a feature of asthma, its association with
relevant asthma outcomes remains unclear. The ATLANTIS study was designed to identify …

Airway inflammation in COPD: progress to precision medicine

C Brightling, N Greening - European Respiratory Journal, 2019 - Eur Respiratory Soc
Chronic obstructive pulmonary disease (COPD) is a significant cause of morbidity and
mortality worldwide, and its prevalence is increasing. Airway inflammation is a consistent …

Single inhaler extrafine triple therapy in uncontrolled asthma (TRIMARAN and TRIGGER): two double-blind, parallel-group, randomised, controlled phase 3 trials

JC Virchow, P Kuna, P Paggiaro, A Papi, D Singh… - The Lancet, 2019 - thelancet.com
Background To date, no studies have assessed the efficacy of single-inhaler triple therapy in
asthma. Here we report on two studies that compared the single-inhaler extrafine …

Prevalence and risk factors of small airway dysfunction, and association with smoking, in China: findings from a national cross-sectional study

D Xiao, Z Chen, S Wu, K Huang, J Xu… - The Lancet …, 2020 - thelancet.com
Background Small airway dysfunction is a common but neglected respiratory abnormality.
Little is known about its prevalence, risk factors, and prognostic factors in China or anywhere …

Minimal clinically important difference for asthma endpoints: an expert consensus report

M Bonini, M Di Paolo, D Bagnasco… - European …, 2020 - Eur Respiratory Soc
Minimal clinically important difference (MCID) can be defined as the smallest change or
difference in an outcome measure that is perceived as beneficial and would lead to a …

[HTML][HTML] Targeting downstream type 2 cytokines or upstream epithelial alarmins for severe asthma

R Chan, K Stewart, R Misirovs, BJ Lipworth - The Journal of Allergy and …, 2022 - Elsevier
Biologics, including omalizumab, mepolizumab, benralizumab, and dupilumab, targeting
downstream IgE, cytokines IL-5, and IL-4/13, respectively, have shown promising effects in …

Benralizumab effectiveness in severe eosinophilic asthma with and without chronic rhinosinusitis with nasal polyps: a real-world multicenter study

S Nolasco, C Crimi, C Pelaia, A Benfante… - The Journal of Allergy …, 2021 - Elsevier
Background Chronic rhinosinusitis with nasal polyps (CRSwNP) affects around 60% of
patients with severe eosinophilic asthma (SEA). Benralizumab was recently approved for …