TREM2 variants have been identified as risk factors for Alzheimer's disease (AD) and other
neurodegenerative diseases (NDDs). Because TREM2 encodes a receptor exclusively …

Aging is the main risk factor for neurodegenerative diseases. In aging, microglia undergoes
phenotypic changes compatible with their activation. Glial activation can lead to …

In this study, we investigated lipopolysaccharide (LPS)-induced cognitive impairment and
neuroinflammation in C57BL/6J mice by using behavioral tests, immunofluorescence …

Increasing evidence underlines that prototypical inflammatory cytokines (IL-1β, TNF-α and IL-
6) either synthesized in the central (CNS) or peripheral nervous system (PNS) by resident …

Epilepsy is the third most common chronic brain disorder, and is characterized by an
enduring predisposition to generate seizures. Despite progress in pharmacological and …

Biochemical and neuropathological studies of brains from individuals with Alzheimer
disease (AD) provide clear evidence for an activation of inflammatory pathways, and long …

Context Autism is a heterogeneous disorder with genetic and environmental factors likely
contributing to its origins. Examination of hazardous pollutants has suggested the …

Lipopolysaccharide (LPS) is a cell-wall immunostimulatory endotoxin component of Gram-
negative bacteria. A growing body of evidence reveals that alterations in the bacterial …

An unexpected role for the classical complement cascade in the elimination of central
nervous system (CNS) synapses has recently been discovered. Complement proteins are …

The purinergic transmitter ATP (adenosine 5′-triphosphate) plays an essential role in both
the central and peripheral nervous systems, and the ability to directly measure extracellular …