What is polypharmacy? A systematic review of definitions

N Masnoon, S Shakib, L Kalisch-Ellett, GE Caughey - BMC geriatrics, 2017 - Springer
Background Multimorbidity and the associated use of multiple medicines (polypharmacy), is
common in the older population. Despite this, there is no consensus definition for …

Associations of polypharmacy and inappropriate medications with adverse outcomes in older adults with cancer: a systematic review and meta‐analysis

MR Mohamed, E Ramsdale, KP Loh, A Arastu… - The …, 2020 - academic.oup.com
Background Polypharmacy (PP) and potentially inappropriate medications (PIM) are highly
prevalent in older adults with cancer. This study systematically reviews the associations of …

Is polypharmacy associated with frailty in older people? Results from the ESTHER cohort study

KU Saum, B Schöttker, AD Meid… - Journal of the …, 2017 - Wiley Online Library
Objectives To investigate the relationship between polypharmacy and frailty. Design
Longitudinal, observational cohort study. Setting Saarland, Germany. Participants 3,058 …

Polypharmacy, potentially inappropriate medications, and drug-drug interactions in vulnerable older adults with advanced cancer initiating cancer treatment

E Ramsdale, M Mohamed, V Yu, E Otto, K Juba… - The …, 2022 - academic.oup.com
Purpose Polypharmacy is prevalent in older adults starting cancer treatment and associated
with potentially inappropriate medications (PIM), potential drug-drug interactions (DDI), and …

Polypharmacy and potentially inappropriate medication use in geriatric oncology

M Sharma, KP Loh, G Nightingale, SG Mohile… - Journal of geriatric …, 2016 - Elsevier
Polypharmacy is a highly prevalent problem in older persons, and is challenging to assess
and improve due to variations in definitions of the problem and the heterogeneous methods …

Continuing to broaden eligibility criteria to make clinical trials more representative and inclusive: ASCO–friends of cancer research joint research statement

ES Kim, TS Uldrick, C Schenkel, SS Bruinooge… - Clinical Cancer …, 2021 - AACR
Purpose: Restrictive clinical trial eligibility criteria (EC) limit the number of patients who can
enroll and potentially benefit from protocol-driven, investigational treatment plans and …

Polypharmacy in patients with advanced cancer and the role of medication discontinuation

TW LeBlanc, MJ McNeil, AH Kamal, DC Currow… - The Lancet …, 2015 - thelancet.com
Polypharmacy is a well known problem in elderly patients in general, but its prevalence and
effects in patients with cancer are less clear, particularly in end-of-life settings. This Review …

Association of polypharmacy and hyperpolypharmacy with frailty states: a systematic review and meta-analysis

K Palmer, ER Villani, DL Vetrano, A Cherubini… - European Geriatric …, 2019 - Springer
Abstract Purpose To investigate:(1) the cross-sectional association between polypharmacy,
hyperpolypharmacy and presence of prefrailty or frailty;(2) the risk of incident prefrailty or …

Polypharmacy cut-points in older people with cancer: how many medications are too many?

JP Turner, KM Jamsen, S Shakib, N Singhal… - Supportive Care in …, 2016 - Springer
Purpose Polypharmacy is often defined as use of 'five-or-more-medications'. However, the
optimal polypharmacy cut-point for predicting clinically important adverse events in older …

Polypharmacy among older Australians, 2006–2017: a population‐based study

AT Page, MO Falster, M Litchfield… - Medical Journal of …, 2019 - Wiley Online Library
Objective To estimate the prevalence of polypharmacy among Australians aged 70 years or
more, 2006–2017. Design, setting and participants Analysis of a random 10% sample of …