Simple Summary The unfolded protein response (UPR) is the cells' way of maintaining the
balance of protein folding in the endoplasmic reticulum, which is the section of the cell …

Endoplasmic reticulum (ER) is a dynamic organelle orchestrating the folding and post-
translational maturation of almost all membrane proteins and most secreted proteins. These …

Despite substantial advances in targeting mutant KRAS, tumor resistance to KRAS inhibitors
(KRASi) remains a major barrier to progress. Here, we report proteostasis reprogramming as …

Execution of fundamental cellular functions demands regulated protein folding homeostasis.
Endoplasmic reticulum (ER) is an active organelle existing to implement this function by …

Secretory and transmembrane proteins enter the endoplasmic reticulum (ER) as unfolded
proteins and exit as either folded proteins in transit to their target organelles or as misfolded …

▪ Abstract In the endoplasmic reticulum (ER), secretory and transmembrane proteins fold into
their native conformation and undergo posttranslational modifications important for their …

Ischemic stroke is an acute cerebrovascular disease characterized by sudden interruption of
blood flow in a certain part of the brain, leading to serious disability and death. At present …

Conformational diseases are caused by mutations altering the folding pathway or final
conformation of a protein. Many conformational diseases are caused by mutations in …

The accumulation of unfolded proteins in the lumen of the endoplasmic reticulum (ER)
induces a coordinated adaptive program called the unfolded protein response (UPR). The …

Inositol-requiring enzyme type 1 (IRE1) is a serine/threonine kinase acting as one of three
branches of the Unfolded Protein Response (UPR) signaling pathway, which is activated …