Single-cell atlases promise to provide a 'missing link'between genes, diseases and
therapies. By identifying the specific cell types, states, programs and contexts where disease …

Next-generation DNA sequencing technology has dramatically advanced clinical oncology
through the identification of therapeutic targets and molecular biomarkers, leading to the …

Anosmia, the loss of smell, is a common and often the sole symptom of COVID-19. The onset
of the sequence of pathobiological events leading to olfactory dysfunction remains obscure …

Meningiomas are the most common primary intracranial tumour in adults. Patients with
symptoms are generally treated with surgery as there are no effective medical therapies. The …

Acute myeloid leukemia (AML) is a hematopoietic malignancy with poor prognosis and
limited treatment options. Here we provide a comprehensive census of the bone marrow …

Monoclonal antibody therapies targeting tumour antigens drive cancer cell elimination in
large part by triggering macrophage phagocytosis of cancer cells,,,,,–. However, cancer cells …

Deciphering the functional interactions of cells in tissues remains a major challenge. Here
we describe DIALOGUE, a method to systematically uncover multicellular programs (MCPs) …

The SS18-SSX fusion drives oncogenic transformation in synovial sarcoma by bridging
SS18, a member of the mSWI/SNF (BAF) complex, to Polycomb repressive complex 1 …

Tumors are complex tissues of cancerous cells surrounded by a heterogeneous cellular
microenvironment with which they interact. Single-cell sequencing enables molecular …

Human tumors are intricate ecosystems composed of diverse genetic clones and malignant
cell states that evolve in a complex tumor micro-environment. Single-cell RNA-sequencing …