Ubc13-catalyzed K63 ubiquitination is a major control point for immune signaling. Recent
evidence has shown that the control of multiple immune functions, including chronic …

Poxviruses (PXVs) are mostly known for the variola virus, being the cause of smallpox;
however, re-emerging PXVs have also shown a great capacity to develop outbreaks of pox …

Abstract Background Immune checkpoint inhibitors (ICIs) targeting programmed cell death
protein 1 (PD‐1) and programmed death‐ligand 1 (PD‐L1) have shown a moderate …

Cancer immunotherapies, including immune checkpoint inhibitors and immune pathway–
targeted therapies, are promising clinical strategies for treating cancer. However, drug …

The tumor necrosis factor receptor (TNFR)-associated factor (TRAF) family of molecules are
intracellular signaling adaptors and control diverse signaling pathways mediated not only by …

Diabetic foot ulcer (DFU) is a serious complication of diabetes. Elabela (ELA), a ligand of
apelin receptor (APJ), was shown to promote angiogenesis and suppress inflammation. This …

Innate sensing of viruses by cytosolic nucleic acid sensors is a key feature of anti-viral
immunity against these pathogens. The DNA sensing pathway through the sensor cyclic …

It has been proved that TRAFs family proteins played malfunctioning roles in the
development of human cancers. TRAF7 is the last one of TRAFs family proteins to be found …

Over the last decade, the E3-ubiquitine ligases from IAP (Inhibitor of Apoptosis) family have
emerged as potent regulators of immune response. In immune cells, they control signaling …

Background There was much hard work to study the trastuzumab resistance in HER2-
positive gastric cancer (GC), but the information which would reveal this abstruse …