Severe acute respiratory syndrome-coronavirus 2 (SARS-CoV-2) infection is associated with
a diverse spectrum of neurological complications during the acute and postacute stages …

Since the onset of the coronavirus disease 2019 (COVID-19) pandemic, multiple severe
acute respiratory syndrome coronavirus 2 (SARS-CoV-2) variants with increasing ability to …

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is the RNA virus
responsible for the coronavirus disease 2019 (COVID-19) pandemic. Although SARS-CoV-2 …

While blood antibodies mediate protective immunity in most organs, whether they protect
nasal surfaces in the upper airway is unclear. Using multiple viral infection models in mice …

Pathology studies of SARS-CoV-2 Omicron variants of concern (VOC) are challenged by the
lack of pathogenic animal models. While Omicron BA. 1 and BA. 2 replicate in K18-hACE2 …

LY6E is an antiviral restriction factor that inhibits coronavirus spike-mediated fusion, but the
cell types in vivo that require LY6E for protection from respiratory coronavirus infection are …

Abstract TANK-binding kinase 1 (TBK1) is a key signalling component in the production of
type-I interferons, which have essential antiviral activities, including against SARS-CoV-2 …

Numerous pathogens can infect the olfactory tract, yet the pandemic caused by SARS-CoV-
2 has strongly emphasized the importance of the olfactory mucosa as an immune barrier …

Animal models recapitulating COVID-19 are critical to enhance our understanding of SARS-
CoV-2 pathogenesis. Intranasally inoculated transgenic mice expressing human …

Alongside vaccines, antiviral drugs are becoming an integral part of our response to the
SARS‐CoV‐2 pandemic. Nirmatrelvir—an orally available inhibitor of the 3‐chymotrypsin …