Myelin is a multilayer lipid membrane structure that wraps and insulates axons, allowing for
the efficient propagation of action potentials. During developmental myelination of the …

The transcription factors Olig2 and Sox10 jointly define oligodendroglial identity. Because of
their continuous presence during development and in the differentiated state they shape the …

Proper myelination of axons is crucial for normal sensory, motor, and cognitive function.
Abnormal myelination is seen in brain disorders such as major depressive disorder (MDD) …

Studies on the development of central nervous system (CNS) primarily rely on the use of
specific molecular markers for different types of neural cells. S100B is widely being used as …

Glial cells play crucial roles in brain homeostasis and pathogenesis of central nervous
system (CNS) injuries and diseases. However, the roles of these cells and the molecular …

Myelination is an evolutionary recent differentiation program that has been independently
acquired in vertebrates by Schwann cells in the peripheral nervous system and …

Nanophthalmos is a rare, potentially devastating eye condition characterized by small eyes
with relatively normal anatomy, a high hyperopic refractive error, and frequent association …

The homeodomain protein NK2 homeobox 2 (NKX2-2) is a transcription factor that plays a
critical role in the control of cell fate specification and differentiation in many tissues. In the …

Purpose: Nanophthalmos is a rare genetic disorder commonly characterized by a short axial
length (AL) and severe hyperopia. Mutations that have been identified through Mendelian …

Oligodendrocyte (OL) myelination is a critical process for the neuronal axon function in the
central nervous system. After demyelination occurs because of pathophysiology …