Protein phosphatases act as key regulators of multiple important cellular processes and are
attractive therapeutic targets for various diseases. Although extensive effort has been …

Inflammation is the common pathological basis of autoimmune diseases, metabolic
diseases, malignant tumors, and other major chronic diseases. Inflammation plays an …

We combine advances in neural language modeling and structurally motivated design to
develop D-SCRIPT, an interpretable and generalizable deep-learning model, which predicts …

Platelet-derived growth factor (PDGF) was discovered as a serum-derived component
necessary for the growth of smooth muscle cells, fibroblasts, and glial cells. The PDGF family …

The primary cilium is a signaling compartment that interprets Hedgehog signals through
changes of its protein, lipid, and second messenger compositions. Here, we combine …

Kinase activation and phosphorylation cascades are key to initiate immune cell activation in
response to recognition of antigen and sensing of microbial danger. However, for balanced …

Reversible phosphorylation is a fundamental regulatory mechanism, intricately coordinated
by kinases and phosphatases, two classes of enzymes widely disrupted in human disease …

The Kit proto-oncogene was found as a consequence of the discovery of the feline v-kit
sarcoma oncogene. Stem cell factor (SCF) is the Kit ligand and it mediates Kit dimerization …

Aberrant protein phosphorylation is one of the hallmarks of cancer cells, and in many cases
a prerequisite to sustain tumor development and progression. Like protein kinases, protein …

Phosphatases play key roles in normal physiology and diseases. Studying phosphatases
has been both essential and challenging, and the application of conventional genetic and …