Neurofilament proteins as biomarkers to monitor neurological diseases and the efficacy of therapies
Biomarkers of neurodegeneration and neuronal injury have the potential to improve
diagnostic accuracy, disease monitoring, prognosis, and measure treatment efficacy …
diagnostic accuracy, disease monitoring, prognosis, and measure treatment efficacy …
Neurofilaments and neurofilament proteins in health and disease
Neurofilaments (NFs) are unique among tissue-specific classes of intermediate filaments
(IFs) in being heteropolymers composed of four subunits (NF-L [neurofilament light]; NF-M …
(IFs) in being heteropolymers composed of four subunits (NF-L [neurofilament light]; NF-M …
Neurofilaments: neurobiological foundations for biomarker applications
Interest in neurofilaments has risen sharply in recent years with recognition of their potential
as biomarkers of brain injury or neurodegeneration in CSF and blood. This is in the context …
as biomarkers of brain injury or neurodegeneration in CSF and blood. This is in the context …
Neurofilaments at a glance
Neurofilaments (NFs) are intermediate filaments with a diameter of 10 nm, similar to that of
neurons. Although they are present in perikarya and dendrites, neurofilaments are …
neurons. Although they are present in perikarya and dendrites, neurofilaments are …
Much more than a scaffold: cytoskeletal proteins in neurological disorders
DC Muñoz-Lasso, C Romá-Mateo, FV Pallardó… - Cells, 2020 - mdpi.com
Recent observations related to the structure of the cytoskeleton in neurons and novel
cytoskeletal abnormalities involved in the pathophysiology of some neurological diseases …
cytoskeletal abnormalities involved in the pathophysiology of some neurological diseases …
Review of the multiple aspects of neurofilament functions, and their possible contribution to neurodegeneration
R Perrot, R Berges, A Bocquet, J Eyer - Molecular neurobiology, 2008 - Springer
Neurofilaments (NF) are the most abundant cytoskeletal component of large myelinated
axons from adult central and peripheral nervous system. Here, we provide an overview of …
axons from adult central and peripheral nervous system. Here, we provide an overview of …
Elevated neurofilament levels in neurological diseases
N Norgren, L Rosengren, T Stigbrand - Brain research, 2003 - Elsevier
Neurofilaments, a major cytoskeletal constituent of neuronal cells, can be released into the
cerebrospinal fluid during several neurodegenerative diseases. By means of a new …
cerebrospinal fluid during several neurodegenerative diseases. By means of a new …
Neurofilament assembly and function during neuronal development
Studies on the assembly of neuronal intermediate filaments (IFs) date back to the early work
of Alzheimer. Developing neurons express a series of IF proteins, sequentially, at distinct …
of Alzheimer. Developing neurons express a series of IF proteins, sequentially, at distinct …
Neurofilament proteins in neurodegenerative diseases
Q Liu, F Xie, SL Siedlak, A Nunomura, K Honda… - Cellular and Molecular …, 2004 - Springer
The function of neurofilaments, the major component in large myelinated neurons, is not well
understood even though they were discovered as structures over 100 years ago. Recent …
understood even though they were discovered as structures over 100 years ago. Recent …
Neurofilament light regulates axon caliber, synaptic activity, and organelle trafficking in cultured human motor neurons
MT Sainio, T Rasila, SM Molchanova… - Frontiers in cell and …, 2022 - frontiersin.org
Neurofilament light (NFL) is one of the proteins forming multimeric neuron-specific
intermediate filaments, neurofilaments, which fill the axonal cytoplasm, establish caliber …
intermediate filaments, neurofilaments, which fill the axonal cytoplasm, establish caliber …