Organoelement chemistry: Promising growth areas and challenges

GA Abakumov, AV Piskunov… - Russian Chemical …, 2018 - iopscience.iop.org
The chemistry of organoelement compounds is now one of the most rapidly developing
fields of research, regarding both fundamental science and solution of applied problems …

Advances in the chemistry of natural and semisynthetic topoisomerase I/II inhibitors

VA D'yakonov, LU Dzhemileva… - Studies in natural products …, 2017 - Elsevier
The search for new, effective, and low-toxic anticancer agents is one of the most important
tasks of modern medicinal chemistry. In general, the solution to this problem comes down to …

Metallacomplex catalysis in the synthesis of regular isoprenoids

UM Dzhemilev, LU Dzhemileva… - Russian Chemical Bulletin, 2023 - Springer
This brief review covers and systematizes the key results acquired using metal complex
catalysts in both fundamental and applied research aimed at the development of methods …

Synthesis of macrocyclic and linear compounds with 1Z,5Z-diene and alkynylcarbinol fragments based on (5Z,9Z)-tetradeca-5,9-diene-1,14-diol

II Islamov, AA Makarov, EK Makarova… - Russian Chemical …, 2023 - Springer
The stereoselective synthesis of (5 Z, 9 Z)-tetradeca-5, 9-diene-1, 14-diol was carried out by
the catalytic homo-cyclomagnesiation of oxygen-containing 1, 2-diene. Selective syntheses …

Natural compounds with bis-methylene-interrupted Z-double bonds: plant sources, strategies of total synthesis, biological activity, and perspectives

VA D'yakonov, LU Dzhemileva, UM Dzhemilev - Phytochemistry Reviews, 2021 - Springer
The review summarizes data on natural compounds including higher carboxylic acids,
acetogenins, lembehynes, and insect pheromones containing bis-methylene-interrupted Z …

New 1Z, 5Z-diene macrodiolides: Catalytic synthesis, anticancer activity, induction of mitochondrial apoptosis, and effect on the cell cycle

LU Dzhemileva, VA D'yakonov, II Islamov… - Bioorganic …, 2020 - Elsevier
An original scheme was developed for the synthesis of previously undescribed unsaturated
macrodiolides containing a 1Z, 5Z-diene moiety in 44–80% yields and with high …

Recent progress of novel steroid derivatives and their potential biological properties

S Ke - Mini reviews in medicinal chemistry, 2018 - ingentaconnect.com
Steroid and its derivatives have been proved to have important and diverse biological
functions, which present the wide spectrum of biological activities such as antitumor …

Targeted synthesis of macrodiolides containing bis-methylene-separated Z-double bonds and their antitumor activity in vitro

VA D'yakonov, II Islamov, LU Dzhemileva… - Tetrahedron, 2018 - Elsevier
An original strategy has been developed for the synthesis of valuable unsaturated
macrocyclic lactones, macrodiolides, containing a 1Z, 5Z-diene moiety in 57–79% yields …

New synthetic analogues of natural 5Z, 9Z-dienoic acids: Stereoselective synthesis and study of the anticancer activity

AA Makarov, LU Dzhemileva, AR Salimova… - Bioorganic …, 2020 - Elsevier
A stereoselective method was developed for the synthesis of synthetic analogues of natural
5Z, 9Z-dienoic acids by esterification of aliphatic and aromatic alcohols and carboxylic acids …

Synthesis of polyether macrodiolides based on acetylenic derivatives of (5Z,9Z)-tetradeca-5,9-diene-1,14-dioic acid

II Islamov, AV Yusupova, VA D'yakonov… - Russian Chemical …, 2023 - Springer
The stereoselective synthesis of (5 Z, 9 Z)-tetradeca-5, 9-diene-1, 14-dioic acid was carried
out using Ti-catalyzed homo-cyclomagnesiation of 2-(hepta-5, 6-dien-1-yloxy) tetrahydro-2 …