Metabolic pathway gene clusters in filamentous fungi

NP Keller, TM Hohn - Fungal Genetics and Biology, 1997 - Elsevier
Clusters of functionally related genes are a general feature of prokaryotic gene organization
but are much less prevalent in eukaryotes. The discovery that genes for certain types of …

Trichothecene biosynthesis in Fusarium species: chemistry, genetics, and significance

AE Desjardins, TM Hohn… - Microbiological …, 1993 - Am Soc Microbiol
Several species of the genus Fusarium and related fungi produce trichothecenes which are
sesquiterpenoid epoxides that act as potent inhibitors of eukaryotic protein synthesis …

Comparative genomics reveals high biological diversity and specific adaptations in the industrially and medically important fungal genus Aspergillus

RP De Vries, R Riley, A Wiebenga, G Aguilar-Osorio… - Genome biology, 2017 - Springer
Abstract Background The fungal genus Aspergillus is of critical importance to humankind.
Species include those with industrial applications, important pathogens of humans, animals …

Comprehensive annotation of secondary metabolite biosynthetic genes and gene clusters of Aspergillus nidulans, A. fumigatus, A. niger and A. oryzae

DO Inglis, J Binkley, MS Skrzypek, MB Arnaud… - BMC microbiology, 2013 - Springer
Background Secondary metabolite production, a hallmark of filamentous fungi, is an
expanding area of research for the Aspergilli. These compounds are potent chemicals …

Genes, gene clusters, and biosynthesis of trichothecenes and fumonisins in Fusarium

NJ Alexander, RH Proctor, SP McCormick - Toxin reviews, 2009 - Taylor & Francis
Trichothecenes and fumonisins are mycotoxins produced by Fusarium, a filamentous fungus
that can cause disease in barley, maize, rice, wheat, and some other crop plants. Research …

Strategies for mining fungal natural products

P Wiemann, NP Keller - Journal of Industrial Microbiology and …, 2014 - academic.oup.com
Fungi are well known for their ability to produce a multitude of natural products. On the one
hand their potential to provide beneficial antibiotics and immunosuppressants has been …

Developing Aspergillus as a host for heterologous expression

D Lubertozzi, JD Keasling - Biotechnology advances, 2009 - Elsevier
Filamentous fungi have long been used for production of a range of valuable products; with
the advent of molecular biology, it became apparent that these fungi possess considerable …

The current status of natural products from marine fungi and their potential as anti-infective agents

P Bhadury, BT Mohammad… - Journal of Industrial …, 2006 - academic.oup.com
A growing number of marine fungi are the sources of novel and potentially life-saving
bioactive secondary metabolites. Here, we have discussed some of these novel …

The VeA regulatory system and its role in morphological and chemical development in fungi

AM Calvo - Fungal Genetics and Biology, 2008 - Elsevier
In fungi, the velvet gene, or veA, is involved in the regulation of diverse cellular processes,
including control of asexual and sexual development as well as secondary metabolism. This …

Genetic improvement of processes yielding microbial products

JL Adrio, AL Demain - FEMS microbiology reviews, 2006 - academic.oup.com
Although microorganisms are extremely good in presenting us with an amazing array of
valuable products, they usually produce them only in amounts that they need for their own …