A review of digital microfluidics as portable platforms for lab-on a-chip applications

E Samiei, M Tabrizian, M Hoorfar - Lab on a Chip, 2016 - pubs.rsc.org
Following the development of microfluidic systems, there has been a high tendency towards
developing lab-on-a-chip devices for biochemical applications. A great deal of effort has …

MicroRNA biomarkers for infectious diseases: from basic research to biosensing

L Tribolet, E Kerr, C Cowled, AGD Bean… - Frontiers in …, 2020 - frontiersin.org
In the pursuit of improved diagnostic tests for infectious diseases, several classes of
molecules have been scrutinized as prospective biomarkers. Small (18–22 nucleotide), non …

Polymerase chain reaction in microfluidic devices

CD Ahrberg, A Manz, BG Chung - Lab on a Chip, 2016 - pubs.rsc.org
The invention of the polymerase chain reaction (PCR) has caused a revolution in molecular
biology, giving access to a method of amplifying deoxyribonucleic acid (DNA) molecules …

Recent advances and applications of micromixers

CY Lee, LM Fu - Sensors and Actuators B: Chemical, 2018 - Elsevier
Micromixers are crucial components within micro biomedical systems. This article presents a
comprehensive review of the main state-of-the art applications of micromixers in biomedical …

Microfluidics for detection of exosomes and microRNAs in cancer: State of the art

SM Mousavi, SMA Mahdian, MS Ebrahimi… - … Therapy-Nucleic Acids, 2022 - cell.com
Exosomes are small extracellular vesicles with sizes ranging from 30–150 nanometers that
contain proteins, lipids, mRNAs, microRNAs, and double-stranded DNA derived from the …

Isothermal nucleic acid amplification techniques and their use in bioanalysis

OL Bodulev, IY Sakharov - Biochemistry (Moscow), 2020 - Springer
Recently, there has been a rapid progress in the development of techniques for isothermal
amplification of nucleic acids as an alternative to polymerase chain reaction (PCR). The …

Recent advances in microRNA detection

Y Cheng, L Dong, J Zhang, Y Zhao, Z Li - Analyst, 2018 - pubs.rsc.org
The development of simple, robust, and reliable microRNA (miRNA) detection methods is of
great significance in the studies of the biological function of miRNAs, molecular diagnostics …

Integration of isothermal amplification methods in microfluidic devices: Recent advances

MC Giuffrida, G Spoto - Biosensors and Bioelectronics, 2017 - Elsevier
The integration of nucleic acids detection assays in microfluidic devices represents a highly
promising approach for the development of convenient, cheap and efficient diagnostic tools …

Shifting paradigm of cancer diagnoses in clinically relevant samples based on miniaturized electrochemical nanobiosensors and microfluidic devices

K Mahato, A Kumar, PK Maurya, P Chandra - Biosensors and Bioelectronics, 2018 - Elsevier
Cancer is one of leading causes of death in the world and occurs in more than two hundred
types according to the National Cancer Institute. Its early diagnosis has been remained a …

Peptide nucleic acid-based biosensors for cancer diagnosis

R D'Agata, MC Giuffrida, G Spoto - Molecules, 2017 - mdpi.com
The monitoring of DNA and RNA biomarkers freely circulating in the blood constitutes the
basis of innovative cancer detection methods based on liquid biopsy. Such methods are …