In this review, published peer-reviewed preclinical studies using prime-boost tuberculosis
(TB) vaccine regimens in animal challenge models for tuberculosis have been evaluated …

It has been clearly demonstrated that in vitro, virulent M. tuberculosis can favor necrosis over
apoptosis in infected macrophages, and this has been suggested as a mechanism for …

Despite the fact that the majority of people in tuberculosis (TB)–endemic areas are
vaccinated with the Bacillus Calmette–Guérin (BCG) vaccine, TB remains the leading …

Tuberculosis affects nine million individuals and kills almost two million people every year.
The only vaccine available, Bacillus Calmette-Guerin (BCG), has been used since its …

Almost one century after the discovery of the BCG vaccine, tuberculosis remains a major
cause of global mortality and morbidity, emphasizing the urgent need to design more …

Introduction Mucosal immunity is strongly elicited in early stages of many respiratory and
enteric infections; however, its role in tuberculosis pathogenesis has been scarcely …

Chronic pulmonary inflammation marked predominantly by CD4+ IFN-γ+ cells is the
hallmark of tuberculosis pathogenesis in immunocompetent adults, who are substantially …

The magnitude of the cellular adaptive immune response is critical for the control of
Mycobacterium tuberculosis infection in the chronic phase. In addition, the genetic …

Background Previous studies have established that mycobacterial infections ameliorate
allergic inflammation. However, a non‐infectious approach that controls allergic responses …

Synthetic oligonucleotide ligands that bind to toll-like receptors are known to modulate the
immune response via the activation of antigen presenting cells, and were therefore …