Congenital cataracts, the most common cause of visual impairment and blindness in
children worldwide, have diverse etiologies. According to statistics analysis, about one …

Eye formation is the result of coordinated induction and differentiation processes during
embryogenesis. Disruption of any one of these events has the potential to cause ocular …

Mutations in the transcription factor genes FOXE3, HSF4, MAF, and PITX3 cause congenital
lens defects including cataracts that may be accompanied by defects in other components of …

Disorders of the anterior segment of the eye encompass a variety of clinical presentations
including aniridia, Axenfeld and Rieger anomalies, primary congenital glaucoma, Peters …

Homeobox genes encode sequence-specific transcription factors (SSTFs) that recognize
specific DNA sequences and regulate organogenesis in all eukaryotes. They are essential …

Pediatric cataract represents an important cause of pediatric visual impairment. While both
genetic and environmental causes for pediatric cataract are known, a large proportion …

Neonatal cataracts remain the most common cause of visual loss in children worldwide and
have diverse, often unknown, etiologies. This review summarizes current knowledge about …

The present study aimed to identify the disease‑causing gene of a four‑generation Chinese
family affected with congenital posterior subcapsular cataracts (CPSC), to additionally …

Introduction PITX3 has been reported to be associated with congenital cataracts, anterior
segment mesenchymal dysgenesis, Peters' anomaly, and microphthalmia. In this case, an …

Purpose: To demonstrate the underlying genetic defect that contribute to inherited cataract in
a northern Chinese pedigree. Methods: The study recruited a family pedigree with a …