Deamidated, isomerized, and racemized aspartyl and asparaginyl residues represent a
significant part of the spontaneous damage to proteins that results from the aging process …

This paper reviews the chemical and functional aspects of the posttranslational
modifications of proteins, which are achieved by the addition of various groups to the side …

The spontaneous nonenzymatic deamidation of glutaminyl and asparaginyl residues of
peptides and proteins has been observed both in vitro and in vivo. Deamidation may change …

The prion protein is known to be a copper-binding protein, but affinity and stoichiometry data
for the full-length protein at a physiological pH of 7 were lacking. Furthermore, it was …

Aspartic acid racemization (AAR) represents one of the major types of non-enzymatic
covalent modification that leads to an age-dependent accumulation of abnormal protein in …

While PrP C rearranges in the area of codons 104–113 to form PrP Sc during prion
infections, the events that initiate sporadic Creutzfeldt-Jakob disease are undefined. As Cu …

Nonenzymatic deamidation of peptides and proteins represents an important degradation
reaction occurring in vitro in the course of isolation or storage and in vivo during …

Protein deamidation has been proposed to represent a “molecular clock” that progressively
disrupts protein structure and function in human degenerative diseases and natural aging …

The central event underlying prion diseases involves conformational change of the cellular
form of the prion protein (PrPC) into the disease-associated, transmissible form (PrPSc) …

Spontaneous chemical modifications play an important role in human disease and aging at
the molecular level. Deamidation and isomerization are known to be among the most …