Molecular biology of atherosclerosis

PN Hopkins - Physiological reviews, 2013 - journals.physiology.org
At least 468 individual genes have been manipulated by molecular methods to study their
effects on the initiation, promotion, and progression of atherosclerosis. Most clinicians and …

Contribution of aldosterone to cardiovascular and renal inflammation and fibrosis

NJ Brown - Nature Reviews Nephrology, 2013 - nature.com
The steroid hormone aldosterone regulates sodium and potassium homeostasis.
Aldosterone and activation of the mineralocorticoid receptor also causes inflammation and …

Emerging roles of the mineralocorticoid receptor in pathology: toward new paradigms in clinical pharmacology

F Jaisser, N Farman - Pharmacological reviews, 2016 - ASPET
The mineralocorticoid receptor (MR) and its ligand aldosterone are the principal modulators
of hormone-regulated renal sodium reabsorption. In addition to the kidney, there are several …

Aldosterone: effects on the kidney and cardiovascular system

M Briet, EL Schiffrin - Nature Reviews Nephrology, 2010 - nature.com
Aldosterone, a steroid hormone with mineralocorticoid activity, is mainly recognized for its
action on sodium reabsorption in the distal nephron of the kidney, which is mediated by the …

[HTML][HTML] Immune effects of corticosteroids in sepsis

N Heming, S Sivanandamoorthy, P Meng… - Frontiers in …, 2018 - frontiersin.org
Sepsis, a life-threatening organ dysfunction, results from a dysregulated host response to
invading pathogens that may be characterized by overwhelming systemic inflammation or …

[HTML][HTML] Obesity and kidney disease: from population to basic science and the search for new therapeutic targets

A Whaley-Connell, JR Sowers - Kidney international, 2017 - Elsevier
The global burden of kidney disease is increasing strikingly in parallel with increases in
obesity and diabetes. Indeed, chronic kidney disease (CKD) and end-stage renal disease …

Aldosterone mediates its rapid effects in vascular endothelial cells through GPER activation

R Gros, Q Ding, B Liu… - American Journal of …, 2013 - journals.physiology.org
The importance of the rapid vascular effects of aldosterone is increasingly appreciated.
Through these rapid pathways, aldosterone has been shown to regulate vascular …

Aldosterone and inflammation

KC Gilbert, NJ Brown - Current Opinion in Endocrinology …, 2010 - journals.lww.com
Aldosterone and inflammation : Current Opinion in Endocrinology, Diabetes and Obesity
Aldosterone and inflammation : Current Opinion in Endocrinology, Diabetes and Obesity Log in or …

Reduced hemostatic effects with drospirenone-based oral contraceptives containing estetrol vs. ethinyl estradiol

C Kluft, Y Zimmerman, M Mawet, C Klipping… - Contraception, 2017 - Elsevier
Objective The effects of estetrol (E4), a natural fetal estrogen, combined with drospirenone
(DRSP) were evaluated on plasma levels of sex hormone-binding globulin (SHBG) …

[HTML][HTML] Endothelial dysfunction in primary aldosteronism

ZW Chen, CH Tsai, CT Pan, CH Chou, CW Liao… - International journal of …, 2019 - mdpi.com
Primary aldosteronism (PA) is characterized by excess production of aldosterone from the
adrenal glands and is the most common and treatable cause of secondary hypertension …