The mechanical signals within the extracellular matrix (ECM) regulate cell growth,
proliferation and differentiation, and integrins function as the hub between the ECM and …

Invasive ductal carcinoma (IDC) is the most common histological subtype of malignant
breast cancer (BC), and accounts for 70–80% of all invasive BCs. IDC demonstrates great …

Focal adhesions (FAs) are large, integrin-based protein complexes that link cells to the
extracellular matrix (ECM). FAs form only when and where they are necessary to transmit …

The role of mechanical signals in the proper functioning of organisms is increasingly
recognised, and every cell senses physical forces and responds to them. These forces are …

Talin (herein referring to the talin-1 form), is a cytoskeletal adapter protein that binds integrin
receptors and F-actin, and is a key factor in the formation and regulation of integrin …

Phosphate glasses have several advantages over traditional silicate-based bioglasses but
are inferior in the crucial step of cell attachment to their surface. Here, as a proof of concept …

Adhesion of cells to the extracellular matrix (ECM) must be exquisitely coordinated to enable
development and tissue homeostasis. Cell–ECM interactions are regulated by multiple …

Talin-1 is one of the major scaffold proteins in focal adhesions playing a vital role in cell
migration, metastasis, and cancer progression. Although studies regarding the importance of …

Although cell-derived matrices are at the forefront of scientific research and technological
innovation for the development of in vitro tumour models, their two-dimensional structure …

Abstract Variants of talin-1 (TLN1) have recently been linked with spontaneous coronary
artery dissection (SCAD) a condition where a tear can form in the wall of a heart artery …