Classification of diabetic retinopathy: Past, present and future

Z Yang, TE Tan, Y Shao, TY Wong, X Li - Frontiers in Endocrinology, 2022 - frontiersin.org
Diabetic retinopathy (DR) is a leading cause of visual impairment and blindness worldwide.
Since DR was first recognized as an important complication of diabetes, there have been …

Neurodegeneration in the diabetic eye: new insights and therapeutic perspectives

R Simo, C Hernández - Trends in Endocrinology & Metabolism, 2014 - cell.com
Diabetic retinopathy (DR), one of the leading causes of preventable blindness, has been
considered a microcirculatory disease of the retina. However, there is emerging evidence to …

Human vitreous in proliferative diabetic retinopathy: characterization and translational implications

IM Nawaz, S Rezzola, A Cancarini, A Russo… - Progress in retinal and …, 2019 - Elsevier
Diabetic retinopathy (DR) is one of the leading causes of visual impairment in the working-
age population. DR is a progressive eye disease caused by long-term accumulation of …

Neurodegeneration in the pathogenesis of diabetic retinopathy: molecular mechanisms and therapeutic implications

M S. Stem, T W. Gardner - Current medicinal chemistry, 2013 - benthamdirect.com
Diabetic retinopathy (DR), commonly classified as a microvascular complication of diabetes,
is now recognized as a neurovascular complication or sensory neuropathy resulting from …

Therapeutic uses of somatostatin and its analogues: current view and potential applications

U Rai, TR Thrimawithana, C Valery… - Pharmacology & …, 2015 - Elsevier
Somatostatin is an endogeneous cyclic tetradecapeptide hormone that exerts multiple
biological activities via five ubiquitously distributed receptor subtypes. Classified as a broad …

Diabetic retinal neurodegeneration as a form of diabetic retinopathy

D Soni, P Sagar, B Takkar - International Ophthalmology, 2021 - Springer
Purpose To review the evidence supporting diabetic retinal neurodegeneration (DRN) as a
form of diabetic retinopathy. Method Review of literature. Results DRN is recognized to be a …

[HTML][HTML] Neurodegeneration: an early event of diabetic retinopathy

M Villarroel, A Ciudin, C Hernández… - World journal of …, 2010 - ncbi.nlm.nih.gov
Diabetic retinopathy (DR) has been classically considered to be a microcirculatory disease
of the retina caused by the deleterious metabolic effects of hyperglycemia per se and the …

Neurodegeneration is an early event in diabetic retinopathy: therapeutic implications

R Simó, C Hernández… - British Journal of …, 2012 - bjo.bmj.com
Diabetic retinopathy (DR) remains the leading cause of blindness among working-age
individuals in developed countries. Current treatments for DR are indicated in advanced …

Topical administration of somatostatin prevents retinal neurodegeneration in experimental diabetes

C Hernández, M García-Ramírez, L Corraliza… - Diabetes, 2013 - Am Diabetes Assoc
Retinal neurodegeneration is an early event in the pathogenesis of diabetic retinopathy
(DR). Somatostatin (SST) is an endogenous neuroprotective peptide that is downregulated …

Lipid peroxidation: pathophysiological and pharmacological implications in the eye

YF Njie-Mbye, M Kulkarni-Chitnis, CA Opere… - Frontiers in …, 2013 - frontiersin.org
Oxygen-derived free radicals such as hydroxyl and hydroperoxyl species have been shown
to oxidize phospholipids and other membrane lipid components leading to lipid …