Platelet lifespan and mechanisms for clearance

O An, C Deppermann - Current Opinion in Hematology, 2024 - journals.lww.com
Although we have recently gained some insight into how aged platelets are cleared from
circulation, we are still not seeing the full picture. Further investigations of the platelet …

The Ways of the Virus: Interactions of Platelets and Red Blood Cells with SARS-CoV-2, and Their Potential Pathophysiological Significance in COVID-19

MA Panteleev, AN Sveshnikova… - International Journal of …, 2023 - mdpi.com
The hematological effects of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-
2) are important in COVID-19 pathophysiology. However, the interactions of SARS-CoV-2 …

Desialylated platelet clearance in the liver is a novel mechanism of systemic immunosuppression

J Li, D Karakas, F Xue, Y Chen, G Zhu, YH Yucel… - Research, 2023 - spj.science.org
Platelets are small, versatile blood cells that are critical for hemostasis/thrombosis. Local
platelet accumulation is a known contributor to proinflammation in various disease states …

Integrin α5β1 contributes to cell fusion and inflammation mediated by SARS-CoV-2 spike via RGD-independent interaction

H Zhang, Z Wang, HTT Nguyen… - Proceedings of the …, 2023 - National Acad Sciences
The Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) virus infects host cells
by engaging its spike (S) protein with human ACE2 receptor. Recent studies suggest the …

SARS-CoV-2 spike protein potentiates platelet aggregation via upregulating integrin αIIbβ3 outside-in signaling pathway

R Wang, Z Tian, M Zhu, B Zhang, Y Li, Y Zheng… - Journal of Thrombosis …, 2024 - Springer
Platelet hyperreactivity is one of the crucial causes of coagulative disorders in patients with
COVID-19. Few studies have indicated that integrin αIIbβ3 may be a potential target for spike …

Cathelicidin-HG Alleviates Sepsis-Induced Platelet Dysfunction by Inhibiting GPVI-Mediated Platelet Activation

W Xiong, J Chai, J Wu, J Li, W Lu, M Tian, MA Jmel… - Research, 2024 - spj.science.org
Platelet activation contributes to sepsis development, leading to microthrombosis and
increased inflammation, which results in disseminated intravascular coagulation and …

Salvianolic Acid B Inhibits Thrombosis and Directly Blocks the Thrombin Catalytic Site

MAD Neves, TT Ni, DT Mackeigan, AA Shoara… - Research and Practice …, 2024 - Elsevier
Abstract Background Salvianolic acid B (SAB) is a major component of Salvia miltiorrhiza
root (Danshen), widely used in East/Southeast Asia for centuries to treat cardiovascular …

SALM: Sequence-Structure Pre-trained Large Language Model for Comprehensive Antibody Representation Learning

M Yin, H Zhou, J Wu, Y Zhu, Y Zhan, Z Kong… - arXiv preprint arXiv …, 2024 - arxiv.org
Antibodies safeguard our health through their precise and potent binding to specific
antigens, demonstrating promising therapeutic efficacy in the treatment of numerous …

1, 25‐Dihydroxyvitamin D3 attenuates platelet aggregation potentiated by SARS‐CoV‐2 spike protein via inhibiting integrin αIIbβ3 outside‐in signaling

R Wang, Z Tian, C Wang, B Zhang… - Cell Biochemistry and …, 2024 - Wiley Online Library
Platelet hyperreactivity contributes to the pathogenesis of COVID‐19, which is associated
with a hypercoagulability state and thrombosis disorder. It has been demonstrated that …

Structural analyses of apolipoprotein A-IV polymorphisms Q360H and T347S elucidate the inhibitory effect against thrombosis

AA Shoara, S Slavkovic, M Neves, P Bhoria, V Prifti… - bioRxiv, 2024 - biorxiv.org
Apolipoprotein A-IV (apoA-IV) is an abundant lipid-binding protein in blood plasma. We
previously reported that apoA-IV, as an endogenous inhibitor, competitively binds platelet …