As for all other drugs, antibiotics must reach their pharmacodynamic target in order to exert
their effect, but because infection may occur in various tissues the distribution of antibiotics …

Colistin is an old antibiotic that has recently gained a considerable renewal of interest for the
treatment of pulmonary infections due to multidrug-resistant Gram-negative bacteria …

Among the most important perioperative considerations for the surgical patient is
antimicrobial therapy. The Center for Disease Control Healthcare-Associated Infections …

Pneumonia is a form of lung infection that may be caused by various micro-organisms. The
predominant site of infection in pneumonia is debatable. Advances in the fields of diagnostic …

Objectives The aim of this study was to evaluate the effect of colistin methanesulphonate
(CMS) dose on CMS and colistin pharmacokinetics in rats. Methods Three rats per group …

Objective Target-site concentrations obtained via the catheter-based minimally invasive
microdialysis technique often exhibit high variability. Catheter calibration is commonly …

Introduction Extremity tourniquet (TNK) application is an effective means of achieving
compressible hemorrhage control in the emergency prehospital and clinical trauma setting …

Introduction The objectives of this study were to characterize antimicrobial drug penetration
into the pulmonary epithelial lining fluid (PELF) and extracellular fluid (ECF) of muscle in …

Purpose The objective of this study was to compare two different nebulizers: Eflow rapid®
and Pari LC star® by scintigraphy and PK modeling to simulate epithelial lining fluid …

Background: Microdialysis studies of antibacterial tissue distribution in critically ill patients
have sometimes led to results that were spectacular but inconsistent with basic …