Hydrolases are well-known for hydrolyzing esters, amides, carbamates, peptides, or acid
anhydrides in the presence of water. However, some of them are also capable of catalyzing …

Heterogeneous biocatalysis is highly relevant in biotechnology as it offers several benefits
and practical uses. To leverage the full potential of heterogeneous biocatalysts, the …

Thermostability enhancement is a fundamental aspect of protein engineering as a
biocatalyst's half-life is key for its industrial and biotechnological application, particularly at …

Immobilized multienzyme systems are gaining momentum in applied biocatalysis; however,
the coimmobilization of several enzymes on one carrier is still challenging. In this work, we …

β-Hydroxy esters are essential building blocks utilised by the pharmaceutical and food
industries in the synthesis of functional products. The asymmetric reduction of β-keto esters …

Flow chemistry as well as biocatalysis contribute to achieve green industries and
sustainable development. Now there is an approach that combines them, called flow …

Abstract tert-Butyl 6-cyano-(3R, 5R)-dihydroxyhexanoate ((3R, 5R)-2), an important
precursor of atorvastatin, can be synthesized through asymmetric reduction of tert-butyl 6 …

Biocatalysis in continuous flow systems is an appealing strategy for efficient and
environmentally sustainable manufacturing of value-added compounds. Here, a robust …

This study identifies new acyl donors for manufacturing statin analogues through the
acylation of monacolin J acid by the laboratory evolved acyltransferase LovD9. Vinyl and p …

Sustainable biocatalysis syntheses have gained considerable popularity over the years.
However, further optimizations–notably to reduce costs–are required if the methods are to …