Ciliopathies are inherited human disorders caused by both motile and non‐motile cilia
dysfunction that form an important and rapidly expanding disease category. Ciliopathies are …

Wnt signal cascade is an evolutionarily conserved, developmental pathway that regulates
embryogenesis, injury repair, and pathogenesis of human diseases. It is well established …

Nephronophthisis (NPHP) is a renal ciliopathy and an autosomal recessive cause of cystic
kidney disease, renal fibrosis, and end-stage renal failure, affecting children and young …

Nephronophthisis (NPHP) is an autosomal recessive cystic kidney disease and is one of the
most frequent genetic causes for kidney failure (KF) in children and adolescents. Over 20 …

The endothelial cells that compose the vascular system in the body display a wide range of
mechanotransductive behaviors and responses to biomechanical stimuli, which act in …

Autosomal dominant polycystic kidney disease (ADPKD) is a progressive inherited disorder
in which renal tissue is gradually replaced with fluid-filled cysts, giving rise to chronic kidney …

Background Proteinuria and glomerular segmental fibrosis are inevitable complications of
diabetic nephropathy though their mechanisms are poorly understood. Understanding the …

Cell polarity refers to the asymmetric distribution of signaling molecules, cellular organelles,
and cytoskeleton in a cell. Neural progenitors and neurons are highly polarized cells in …

Primary microcephaly is a congenital neurodevelopmental disorder of reduced head
circumference and brain volume, with fewer neurons in the cortex of the developing brain …

The primary cilium is an antenna-like organelle that plays a vital role in organ generation
and maintenance. It protrudes from the cell surface where it receives signals from the …