From synapses to circuits, astrocytes regulate behavior

KA Lyon, NJ Allen - Frontiers in neural circuits, 2022 - frontiersin.org
Astrocytes are non-neuronal cells that regulate synapses, neuronal circuits, and behavior.
Astrocytes ensheath neuronal synapses to form the tripartite synapse where astrocytes …

Chemogenetic modulation of astrocytes and microglia: State‐of‐the‐art and implications in neuroscience

J Bossuyt, Y Van Den Herrewegen, L Nestor, A Buckinx… - Glia, 2023 - Wiley Online Library
Insights into the role astrocytes and microglia play in normal and diseased brain functioning
has expanded drastically over the last decade. Recently, chemogenetic tools have emerged …

Astrocytic transcriptional and epigenetic mechanisms of drug addiction

LM Holt, EJ Nestler - Journal of Neural Transmission, 2024 - Springer
Addiction is a leading cause of disease burden worldwide and remains a challenge in
current neuroscience research. Drug-induced lasting changes in gene expression are …

Astrocyte-neuron signaling in the mesolimbic dopamine system: the hidden stars of dopamine signaling

M Corkrum, A Araque - Neuropsychopharmacology, 2021 - nature.com
Astrocytes are fundamental components of brain information processing and possess the
ability to respond to synaptic signaling with increases in cytoplasmic calcium and modulate …

Astrocyte Reactivity and Neurodegeneration in the Female Rat Brain Following Alcohol Dependence

SP Guerin, JK Melbourne, HQ Dang, CA Shaji, K Nixon - Neuroscience, 2023 - Elsevier
Recent evidence suggests that alcohol use disorder (AUD) may manifest itself differently in
women compared to men. Women experience AUDs on an accelerated timeline and may …

Diverging effects of adolescent ethanol exposure on tripartite synaptic development across prefrontal cortex subregions

CD Walker, HG Sexton, J Hyde, B Greene, ML Risher - Cells, 2022 - mdpi.com
Adolescence is a developmental period that encompasses, but is not limited to, puberty and
continues into early adulthood. During this period, maturation and refinement are observed …

Chemogenetics as a neuromodulatory approach to treating neuropsychiatric diseases and disorders

J Song, RV Patel, M Sharif, A Ashokan, M Michaelides - Molecular Therapy, 2022 - cell.com
Chemogenetics enables precise, non-invasive, and reversible modulation of neural activity
via the activation of engineered receptors that are pharmacologically selective to …

Sex-specific effects of adolescent intermittent ethanol exposure-induced dysregulation of hippocampal glial cells in adulthood

KN Nwachukwu, DM King, KL Healey… - Alcohol, 2022 - Elsevier
Adolescent alcohol abuse is a significant public health concern, with approximately 4.3
million US adolescents reporting monthly binge drinking. Excessive ethanol consumption …

The role of astrocytes in behaviors related to emotion and motivation

E Shigetomi, S Koizumi - Neuroscience Research, 2023 - Elsevier
Astrocytes are present throughout the brain and intimately interact with neurons and blood
vessels. Three decades of research have shown that astrocytes reciprocally communicate …

Neuroimmune interactions with binge alcohol drinking in the cerebellum of IL-6 transgenic mice

DL Gruol, D Calderon, K French, C Melkonian… - …, 2023 - Elsevier
The neuroimmune system of the brain, which is comprised primarily of astrocytes and
microglia, regulates a variety of homeostatic mechanisms that underlie normal brain …