[HTML][HTML] The fight against cancer by microgravity: the multicellular spheroid as a metastasis model

D Grimm, H Schulz, M Krüger… - International Journal of …, 2022 - mdpi.com
Cancer is a disease exhibiting uncontrollable cell growth and spreading to other parts of the
organism. It is a heavy, worldwide burden for mankind with high morbidity and mortality …

[HTML][HTML] Current knowledge about the impact of microgravity on gene regulation

TJ Corydon, H Schulz, P Richter, SM Strauch… - Cells, 2023 - mdpi.com
Microgravity (µ g) has a massive impact on the health of space explorers. Microgravity
changes the proliferation, differentiation, and growth of cells. As crewed spaceflights into …

[HTML][HTML] Recent advances in thyroid cancer research

D Grimm - International Journal of Molecular Sciences, 2022 - mdpi.com
This Special Issue (SI)“Recent Advances in Thyroid Cancer Research” covers research
articles and reviews in the field of thyroid cancer research. It includes publications reporting …

Decellularized plant-derived vasculature-on-a-chip interacting with breast cancer spheroids to evaluate a dual-drug therapy

Y Filiz, Y Arslan, E Duran, P Saglam-Metiner… - Applied Materials …, 2024 - Elsevier
Breast cancer progression is a complex process involving the primary tumor and its
microenvironment supported by a vascular network. Multicellular spheroids closely mimic in …

[HTML][HTML] Behavior of glioblastoma brain tumor stem cells following a suborbital rocket flight: Reaching the “edge” of outer space

CA Garcia, P Suárez-Meade, M Brooks, AG Bhargav… - npj …, 2023 - nature.com
The emerging arena of space exploration has created opportunities to study cancer cell
biology in the environments of microgravity and hypergravity. Studying cellular behavior in …

[HTML][HTML] Fluid and Bubble Flow Detach Adherent Cancer Cells to Form Spheroids on a Random Positioning Machine

JL Cortés-Sánchez, D Melnik, V Sandt, S Kahlert… - Cells, 2023 - mdpi.com
In preparing space and microgravity experiments, the utilization of ground-based facilities is
common for initial experiments and feasibility studies. One approach to simulating …

[HTML][HTML] Morphologic and genomic changes of thyroid cancer cell lines exposed to conditions of simulated microgravity

J Ahn, S Park, YM Hwang, YS Choi, JW Yi - npj Microgravity, 2024 - nature.com
Microgravity in space impacts human health. In particular, thyroid cancer, which has a high
incidence rate, has been the subject of numerous studies with respect to microgravity …

[HTML][HTML] Omics Studies of Tumor Cells under Microgravity Conditions

J Graf, H Schulz, M Wehland, TJ Corydon… - International Journal of …, 2024 - mdpi.com
Cancer is defined as a group of diseases characterized by abnormal cell growth, expansion,
and progression with metastasis. Various signaling pathways are involved in its …

Exploring the influence of microgravity on chemotherapeutic drug response in cancer: Unveiling new perspectives

PM Vora, S Prabhu - Journal of Cellular and Molecular …, 2024 - Wiley Online Library
Microgravity, an altered gravity condition prevailing in space, has been reported to have a
profound impact on human health. Researchers are very keen to comprehensively …

Latest knowledge about changes in the proteome in microgravity

H Schulz, SM Strauch, P Richter… - Expert Review of …, 2022 - Taylor & Francis
Introduction A long-term stay of humans in space causes health problems and changes in
protists and plants. Deep space exploration will increase the time humans or rodents will …