A complex systems approach to aging biology

AA Cohen, L Ferrucci, T Fülöp, D Gravel, N Hao… - Nature Aging, 2022 - nature.com
Having made substantial progress understanding molecules, cells, genes and pathways,
aging biology research is now moving toward integration of these parts, attempting to …

Is metabolic rate a universal 'pacemaker'for biological processes?

DS Glazier - Biological Reviews, 2015 - Wiley Online Library
ABSTRACT A common, long‐held belief is that metabolic rate drives the rates of various
biological, ecological and evolutionary processes. Although this metabolic pacemaker view …

Trade-offs (and constraints) in organismal biology

T Garland Jr, CJ Downs… - … and biochemical zoology, 2022 - journals.uchicago.edu
Trade-offs and constraints are inherent to life, and studies of these phenomena play a
central role in both organismal and evolutionary biology. Trade-offs can be defined …

Towards an evolutionary theory of stress responses

B Taborsky, S English, TW Fawcett, B Kuijper… - Trends in ecology & …, 2021 - cell.com
All organisms have a stress response system to cope with environmental threats, yet its
precise form varies hugely within and across individuals, populations, and species. While …

[PDF][PDF] Glucocorticoid-mediated phenotypes in vertebrates: multilevel variation and evolution

M Hau, S Casagrande, JQ Ouyang… - Advances in the Study of …, 2016 - baughlab.org
Fluctuations in abiotic and biotic conditions exist in almost all habitats (Dunlap, Loros, &
DeCoursey, 2004; Stevenson et al., 2015). Some fluctuations like the alternation between …

[PDF][PDF] Integrative physiology of fasting

SM Secor, HV Carey - Compr Physiol, 2016 - researchgate.net
Extended bouts of fasting are ingrained in the ecology of many organisms, characterizing
aspects of reproduction, development, hibernation, estivation, migration, and infrequent …

[HTML][HTML] Aging across the tree of life: The importance of a comparative perspective for the use of animal models in aging

AA Cohen - Biochimica et Biophysica Acta (BBA)-Molecular Basis …, 2018 - Elsevier
Use of model organisms in aging research is problematic because our ability to extrapolate
across the tree of life is not clear. On one hand, there are conserved pathways that regulate …

Homeostatic dysregulation proceeds in parallel in multiple physiological systems

Q Li, S Wang, E Milot, P Bergeron, L Ferrucci… - Aging cell, 2015 - Wiley Online Library
An increasing number of aging researchers believes that multi‐system physiological
dysregulation may be a key biological mechanism of aging, but evidence of this has been …

The comparative biology of environmental stress: behavioural endocrinology and variation in ability to cope with novel, changing environments

JC Wingfield - Animal Behaviour, 2013 - Elsevier
Coping with perturbations of the environment such as severe storms and other climatic
extremes, habitat degradation, changes in predator numbers, invasive species and social …

A novel statistical approach shows evidence for multi-system physiological dysregulation during aging

AA Cohen, E Milot, J Yong, CL Seplaki, T Fülöp… - Mechanisms of ageing …, 2013 - Elsevier
Previous studies have identified many biomarkers that are associated with aging and related
outcomes, but the relevance of these markers for underlying processes and their …