Vertebrates harbor abundant lipopolysaccharide (LPS) in their gut microbiota. Alkaline
phosphatases can dephosphorylate and detoxify the endotoxin component of LPS. Here, we …

Difficulties in fine-mapping quantitative trait loci (QTLs) are a major impediment to progress
in the molecular dissection of complex traits in mice. Here we show that genome-wide high …

Plasma liver-enzyme tests are widely used in the clinic for the diagnosis of liver diseases
and for monitoring the response to drug treatment. There is considerable evidence that …

Metabolic homeostasis is achieved by complex molecular and cellular networks that differ
significantly among individuals and are difficult to model with genetically engineered lines of …

Heavy metals present a threat to human health, even at minimal concentrations within the
body. One source of exposure is due to the consumption of low-level contaminated foodstuff …

Gestational diabetes is a common pregnancy complication that adversely influences the
health and survival of mother and child. Pancreatic islet serotonin signaling plays an …

Glutathione S-transferases (GSTs) form a superfamily defined by their ability to catalyze the
conjugation of glutathione with electrophilic substrates. These enzymes are proposed to …

Compared with rodents and many other animal species, the human cytochrome P450
(P450) Cyp2c gene cluster varies significantly in the multiplicity of functional genes and in …

Alkaline phosphatase (ALP) plays an essential role in the regulation of tissue mineralization,
and its activity is highly heritable. Guided by genetic associations discovered in a murine …

Blood components are considered to reflect nutrient metabolism and immune activity in both
humans and animals. In this study, we measured 12 blood components in Pekin ducks and …