[HTML][HTML] Toward a mechanistic understanding of DNA methylation readout by transcription factors
Epigenetic DNA modification impacts gene expression, but the underlying molecular
mechanisms are only partly understood. Adding a methyl group to a cytosine base locally …
mechanisms are only partly understood. Adding a methyl group to a cytosine base locally …
Structural insights into glucocorticoid receptor function
The glucocorticoid receptor (GR) is a steroid hormone-activated transcription factor that
binds to various glucocorticoid response elements to up-or down-regulate the transcription …
binds to various glucocorticoid response elements to up-or down-regulate the transcription …
Structures of CTCF–DNA complexes including all 11 zinc fingers
The CCCTC-binding factor (CTCF) binds tens of thousands of enhancers and promoters on
mammalian chromosomes by means of its 11 tandem zinc finger (ZF) DNA-binding domain …
mammalian chromosomes by means of its 11 tandem zinc finger (ZF) DNA-binding domain …
Physicochemical models of protein–DNA binding with standard and modified base pairs
DNA-binding proteins play important roles in various cellular processes, but the
mechanisms by which proteins recognize genomic target sites remain incompletely …
mechanisms by which proteins recognize genomic target sites remain incompletely …
Tet2 inactivation enhances the antitumor activity of tumor-infiltrating lymphocytes
Inactivation of tumor-infiltrating lymphocytes (TIL) is one of the mechanisms mitigating
antitumor immunity during tumor onset and progression. Epigenetic abnormalities are …
antitumor immunity during tumor onset and progression. Epigenetic abnormalities are …
[HTML][HTML] Waterborne copper exposure up-regulated lipid deposition through the methylation of GRP78 and PGC1α of grass carp Ctenopharyngodon idella
YH Xu, YC Xu, C Hogstrand, T Zhao, LX Wu… - Ecotoxicology and …, 2020 - Elsevier
Early molecular events after the exposure of heavy metals, such as aberrant DNA
methylation, suggest that DNA methylation was important in regulating physiological …
methylation, suggest that DNA methylation was important in regulating physiological …
Structural basis of DNA methylation-dependent site selectivity of the Epstein–Barr virus lytic switch protein ZEBRA/Zta/BZLF1
F Bernaudat, M Gustems, J Günther… - Nucleic acids …, 2022 - academic.oup.com
Abstract In infected cells, Epstein–Barr virus (EBV) alternates between latency and lytic
replication. The viral bZIP transcription factor ZEBRA (Zta, BZLF1) regulates this cycle by …
replication. The viral bZIP transcription factor ZEBRA (Zta, BZLF1) regulates this cycle by …
[HTML][HTML] Interaction preferences between protein side chains and key epigenetic modifications 5-methylcytosine, 5-hydroxymethycytosine and N6-methyladenine
M Hajnic, S Alonso-Gil, AA Polyansky, A de Ruiter… - Scientific Reports, 2022 - nature.com
Covalent modifications of standard DNA/RNA nucleobases affect epigenetic regulation of
gene expression by modulating interactions between nucleic acids and protein readers. We …
gene expression by modulating interactions between nucleic acids and protein readers. We …
Structural basis of water-mediated cis Watson–Crick/Hoogsteen base-pair formation in non-CpG methylation
SM Lin, HT Huang, PJ Fang, CF Chang… - Nucleic Acids …, 2024 - academic.oup.com
Non-CpG methylation is associated with several cellular processes, especially neuronal
development and cancer, while its effect on DNA structure remains unclear. We have …
development and cancer, while its effect on DNA structure remains unclear. We have …
Preferential CEBP binding to T: G mismatches and increased C-to-T human somatic mutations
DNA cytosine methylation in mammals modulates gene expression and chromatin
accessibility. It also impacts mutation rates, via spontaneous oxidative deamination of 5 …
accessibility. It also impacts mutation rates, via spontaneous oxidative deamination of 5 …