Drug development in oncology is highly challenging, with less than 5% success rate in
clinical trials. This alarming figure points out the need to study in more details the multiple …

The advent of targeted therapies has led to tremendous improvements in treatment options
and their outcomes in the field of oncology. Yet, many cancers outsmart precision drugs by …

Abstract Cancer Drug Resistance publishes contributions to understanding the biology and
consequences of mechanisms that interfere with successful treatment of cancer. Since …

Simple Summary Cutaneous squamous cell carcinoma (cSCC) is a very common skin
cancer with poor prognosis for patients with advanced disease. PI3K/AKT/mTOR and cell …

Cancer drug resistance is a major obstacle to the effectiveness of chemoradiotherapy,
targeted therapy, and immunotherapy. CRISPR/Cas9 library screening has emerged as a …

Synthetic lethality is a phenomenon wherein the simultaneous deficiency of two or more
genes results in cell death, while the deficiency of any individual gene does not lead to cell …

Brain metastasis, characterized by poor clinical outcomes, is a devastating disease. Despite
significant mechanistic and therapeutic advances in recent years, pivotal improvements in …

Pancreatic adenocarcinoma is one of the most aggressive and lethal forms of cancer.
Chemotherapy is the primary treatment for pancreatic cancer, but resistance to the drugs …

It is well known that scientists revel in using their skills to resolve problems and move
technology forward. A stellar example of this concept is the evolution of CRISPR technology …